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Flashcards in Bone/Muscle Phys Basics Deck (11):
0

Collagen type essentials

- Type I: fibrocartilage, bone, dentin
- Type II: cartilage
- Type III: loose/dense CT
- Type IV: basal Laminae
- Type VII: high stress areas (palms, soles)
- Type XI: FACIT linkage collagen
- Type X: epiphyseal marker (Zone of hypertrophy and mineralization)

1

Collagen formation process

- Preprocollagen synthesis
- Hydroxylation of lysines and prolines
- Glycosylation of hydroxylysine and hydroxyproline
- Alpha chains assembled into procollagen (secretory product)
- Procollagen peptide sequences cleaved -> tropocollagen
- tropocollagen Assembled into collagen fibrils

2

Sarcaromere signal transduction

- A/P Transmitted down the sarcolemma -> t tubule
- ryanodine receptor senses voltage delta and opens calcium channels -> SR efflux
- Ca is quickly reuptaken by Ca pumps and sequestered by calcequestrin

3

Troponin/myosin/tropomyosin

- Tropomyosin hides actin binding site from myosin
- troponin T binds tropomyosin
- troponin I binds troponin c and actin
- troponin C binds calcium and pulls on troponin T pulling on tropomyosin exposing binding site

4

Osteopontin

- Promote cell infusion to extra cellular matrix including osteoclasts to bone

5

Chondronectin

- Chondrocyte binding, collagen type II, binding proteoglycan binding

6

1B afferent

- Fibers carrying GTO reflex information

7

Zone of proliferation

- Contains chondrocytes forming isogenous groups in rows
- hGF -> IGF -> mitosis

8

Zone of hypertrophy

- Secretes ALPase -> Begins breaking down the vertical columns between them

9

Type A synoviocytes

- Macrophages well-developed Golgi apparatus and only a small amount of rough ER
- Clears debris from joint space

10

Type B synoviocytes

- Create synovial fluid as ultrafiltrate from blood
- Ultrafiltrate contains hyluronic acid and lubricin