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Flashcards in Bone/Tumors Deck (15):

Two most common benign tumors

- Osteochondroma
- fiberous cortical defect


Tumor composed of woven and lamellar bone frequently deposited in cortical pattern with haversian like systems

Osteoma: typically benign and subclinical


A tumor producing nocturnal pain that is relieved by aspirin in a young male that is less than 2 cm

Osteoid osteomas and osteoblastomas


Bulky tumor with the gritty gray white mass content areas of hemorrhage and cystic degeneration
- This tumor presents with a bimodal distribution: younger than 20 years and the elderly
- knees>hips>maxilla/mandible

- osteosarcoma
- Typically arises from the defect in RB and p53 and occasionally INK4a for a which encodes for p16


Prominent bone extending into soft tissues with radiographic codman triangle

- osteosarcoma


Benign cartilage capped Bony extension

- osteochondroma
- loss of EXT1/EXT2
- typically in long bones or pelvis (rarely in distal extremities)


A small glossy gray blue translucent tumor associated with both Ollier and maffucci syndrome

- 20s and 40s


A rare benign tumor composed of sheets of polyhedral chondroblasts set in scant amounts if hyaline matrix
- typically painful
- assoc with effusion and restriction of movement

- chondroblastoma


Chondromyxoid vs. sarcoma

- chondromyxoid involves lobules of hyaline matrix
- chondrosarcoma also contains malignant, non-uniform and dysplastic cells


A dysplastic tumor arising in the axial skeleton with a nodular growth pattern of endosteal CSalloping



Elongated sharply demarcated radiolucent surrounded by a rim of sclerosis: lobulated
- Yellow brown cellular lesions containing fibroblasts macrophages arranged in storiform pattern

Fibrous cortical defect


Tumors associated with polyostotic disease café au lait skin pigmentation's and precocious puberty
- GNAS mutation

Fiberous dysplasia
- monostotic: lesion involving only one bone - 70%
- polyostotic without endocrine: often involves craniofacial lesions
- polyostotic with endocrine: Café au lait spots sexual Precocity hyperthyroidism
- lesions have storiform, grossly ground glass appearance


Large hemorrhagic tan/white tumors destroying underlying tissue with a herringbone storiform patten

- Fibrosarcoma


A small tan white saw tumor containing areas of hemorrhage and necrosis composed of uniform sheets of small round cells.
- Homer-wright rosettes

Eweing/PNET tumors (neuroectodermal)


Large red-brown tumors that undergo cystic degeneration. There composed of uniform oval mononuclear cells (type and epidem)

- giant cell tumor (osteoclastoma)
- 20-40s