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Flashcards in Drugs Deck (32):
0

Topical retinoids

- Tretinoin, Adapalene, Tazarotine (cat X)
- MOA: Comedolysis, antiinflammatory, normalization of epi
- really common in acne

1

Azelaic acid

- MOA: direct inhibition of P. Acnes, tyrosinase inhibitor (trt hyper pigmentation)
- use: hyper pigmentation

2

Topical dapsone

- MOA: anti-inflammatory, inhibits PMNs, anti-microbial
- if used with benzoyl peroxide -> yellow pigmentation (separate use by 20-30 mins)

3

Erythromycin

- MOA: macrolide (50s subunit inhibition)
- Use: reduce lesions in P. Acnes (second line after tetracycline)
- resistance, GI upset: take with lipid

4

Clindamycin

- MOA: 50s subunit binder: combo with benzoyl peroxide
- Use: decrease # of lesions
- pseudomembranous colitis risk

5

Tetracycline

- MOA: 30s subunit binding
- Use: deep papules or nodules (tetracycline first line microbial)

6

Minocycline

- doxy
- Sx: drug induced lupus (anti histone Ab)
- Sx: pseudo tumor cerebri
- Sx: blue/black pigment

7

Triamicinalone

- MOA: phoslip 2a inhibition
- Use: acne emergencies (acne fulminans)
- use to prevent scarring

8

Isoretinoin

- systemic (oral) retinoic acid derivative CAT X
- MOA: sebum suppression, anti inflammatory
- use: recalcitrant acne
- dryness (related to lack of oils)

9

Psoralen + UVA

- MOA: increases skin sensitivity to light, slows growth of new skin
- use: generalized psoriasis
- Sx: skin cancer

10

Acitretin

- MOA: binds nuclear txn factors, reduce hyperplasia
- Use: psoriasis
- Sx: lipid elevation

11

Methotrexate

- MOA: DHFR inhibition
- Use: psoriasis
- Sx: hepatotoxicity, lung fibrosis

12

Cyclosporine

- MOA: binds cyclophilin -> inhibits calcineurin -> inhibits IL2
- Use: psoriasis
- Sx: nephrotoxicity

13

Azathiopine

- MOA: 6-MP analog -> inhibits de novo purine synthesis
- Use: psoriasis
- Sx: lots

14

Etanerctept, inflixumab, adilimumab

- MOA: cytokine inhibition (TNFa inhibitor)
- Use: psoriasis
- Sx: infection (TB activation)

15

Tacrolimus, pimcrolimus

- MOA: calcineurin inhibition -> IL2 down reg.
- Use: in atopic dermatitis in kids < 2, second line if roids don't work
- risk if neoplasm and tons of others

16

Mupirocin/retapamulin and cephlexin

- MOA: various
- Use: super infected dermatitis

17

Acyclovir

- MOA: antiviral
- use: suspected eczema herpetica

18

Scopolamine

- MOA: percutaneous muscarinic agonist
- use: motion sickness

19

Nitroglycerin

- MOA: NO production -> vasodilation
- Use: angina
- tolerance can develop

20

Clonadine

- MOA: central a-adrenergic agonist
- Use: anti-hypertensive

21

Hormones: combipatch, estradiol, ortho Vera

- hormone replacement, contraceptive (ortho Vera)

22

Fentanyl

- opioid analgesic
- chronic pain management

23

Lidocaine

- topical analgesic/anesthetic
- herpes zoster

24

Testosterone

- applied to sacrotum or lower back
- hormone replacement

25

UVA/UVB therapy

- A penetrates more deeply, Atopic dermatitis
- B is more narrow band, psoriasis

26

Griseofulvin

- treatment of choice for tinea capitis
- MOA: microtubule inhibition

27

Terbenifine, itrocazole

- use: tinea

28

Primetherim ivermectin

- scabies treatment
- use of ivermectin for immunocomp

29

Keratin pearls

- Invasive squama cell carcinoma

30

Vismodegib

- treatment of BCC, in people not candidates for surgery
- MOA: involves inhibition of sonic hedgehog
- cat X

31

Stage IV melanoma trt

- palliative therapy primary
- lpilimumab, vemurafenib (CTLA MoAb, and other)