Review Stuff Flashcards Preview

MSI > Review Stuff > Flashcards

Flashcards in Review Stuff Deck (52):
0

Squamous dysplasia spectrum

- AK: partial thickness atypia
- SCCIS: full thickness atypia
- Met SCC: Full thickness with basal layer infiltration

1

Arthritis that gets better with use including the MCP joint with nodules

RA
- CD4 mediated process

2

Palisading rings of lymphocytes, jaw cyst and PTCH mutation

- Gorlin's syndrome

3

Trabecular bone without cells in lacunae

- necrotic, expect to see wedge shaped infarct
- sequela is osteoarthritis due to collapse of trabeculae

4

Increased melanocytes Without atypia (should resemble lymphocytes)

- normal Nevus

5

Pagetoid spread of melanocytes

Malignant melanoma
- local: Breslow
- met: stage

6

Puzzle piece mosaic lines

- Paget's disease
- upregulation of blasts and clasts

7

Bimodally distributed hard tissue neoplasm

- osteosarcoma

8

Most common hard tissue neoplasm in the elderly

- chondrosarcoma
- axially distributed

9

Most common tumor in kids

- Ewing sarcoma

10

Most common tumor occurring in bone

- Metastatic lesions coming from the prostate in men and the breasts in women

11

Primary cause of mortality in Deschenes's muscular dystrophy

- cardiac failure
- resp failure can support

12

Severely atrophied facial muscles with ring fibers in myositis on biopsy

Myotonic dystrophy

13

Muscle wasting with Panfascicular myocyte lost

Spinal muscular atrophy

14

Trichrome stain yielding parking lot inclusions in mitochondria, weakness with exercise

- mitochondrial myopathy
- neural and cardiac sequelae

15

Glycogen storage disease that effects both muscle and liver

Pompe's disease

16

Inflammatory process showing lymphocytic infiltration in skin and muscle
- adults only
- everyone

- dermatomyocytis: in all ages
- polymyocytis: in adults only

17

Retroperitoneal malignancy

- liposarcoma
- could also be Fibromatosis (desmoid) but less common and more symptoms

18

Benign tumor that acts malignant

Fibromatosis
- recapitulates muscle tissue -> fibrotic mass

19

Leiomyomas vs. leiomyosarcomas

Leiomyomas are fairly common, leiomyosarcomas are quite rare.

20

Erlenmyer flask deformity

- seen in the ends of long bones of osteopetrosis
- carbonic anhydrase II

21

Mutation in TCIRG1

- osteopetrosis
- screws with H pumps decreasing

22

Saddle nose deformity

- associated with metastatic lung cancer appearance



Wegeners

23

Sqstm1 mutation

Found in 50 % of Paget's cases

24

Deep vs. superficial Fibromatoses
- location
- mechanism

- superficial is either palmar, plantar or penile (mechanism unknown)
- deep are associated with musculature of abdomen
~ associatd with APC/B-catenin mutations, and FAP

25

Failure to let go after handshake

Myotonic dystrophy

26

Anticipation, seen with onset in teenagers

Type I MD
- type II is adult onset and shows no anticipation and is less severe

27

DMPK gene mutation

- myotonic dystrophy
- CTG repeats (more repeats, mo sever disease)

28

External opthalmoplegia, neuro symptoms and cardiomyopathy

- mitochondrial myopathy

29

Ragged red fibers and "parking lot" inclusions

Mitochondrial myopathy

30

Threadlike bands of protein derived from a-actinin

Nemaline
- floppy babies
- arthrogryposis: contracture of joints

31

Condition assoc. with thymomas

- myasthenia gravis
- excess production of T cells -> ACh attack

32

Edrophonium

- AChE to diagnose MG
- aka Tensilon test

33

Rhabdomyosarcoma best and worst prognosis

- best = embryonal (botryoid tumor)
- worst = alveolar

34

Dermatomyocytis as a Paraneoplastic syndrome in kids

GI cancer

35

Soap bubble, epiphisial tumor

- giant cell tumor

36

Metaphyseal tumor transformation

- osteosarcoma (benign tumor starts in bone) -> chondrosarcoma

37

Radiolucent core on X-ray, aspirin doesn't relieve pain

- osteoblastomas

38

Tombstone blister morphology

Separation of s. basale from rest: desmosome (desmoglien 1 and 3)

39

Bisphosphonates as treatment

- Paget's disease

40

Velvety darkening of the skin in axilla/groin

- acanthosis nigricans
- associated with gastric carcinoma and TIIDM

41

Saw toothed dermal-epidermal junction, 6 P's

- lichen planus

42

Tizarotine

- cat X
- MOA: comedolytic, normalizes epidermal differentiation, anti inflammatory

43

Guttate psoriasis

- small lesions over trunk and proximal extremities
- preceded by strep throat infection

44

Storiform ground glass appearing tumor associated with precocious puberty

- fiberous dysplasia
- 70% monostic

45

Hair growth signaling genes

WNT - follicle development
Notch - epidermal differentiation

46

Atopic dermatitis pathenogenesis

- fillagrin
- TH2 mediated

47

Tzank smear

HSV detection
- detects giant cells

48

Hutchinsons sign

- herpes zoster papules appearing on nose: get opthalmaic consult

49

Bright red plaques with satillite pustules

Candidiasis
- may be associated with

50

Sabourauds/Mycosel gel

- diagnosis of superficial fungal infection

51

Acral lentiginous melanoma

Palms, soles, nail beds
- most common in dark skinned