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Zak, Endo/Repro 2 > Breast Carcinoma Pathology > Flashcards

Breast Carcinoma Pathology Flashcards

1
Q

Which type of breast carcinoma has an increased risk with age?

A

ER+

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2
Q

What are the major genes associated with Familial breast carcinoma?

A

BRCA1/2, TP53, CHEK2

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3
Q

Which gene is associated with single gene familial breast cancers?

A

BRCA1/2

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4
Q

Which gene is associated with an increased risk of ovarian carcinoma?

A

BRCA1

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5
Q

Which gene is associated with male breast cancer?

A

BRCA2

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6
Q

Which mutations are more likely to be ER+?

A

BRCA2

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7
Q

Which mutations are associated with increased risk of prostatic and pancreatic carcinoma?

A

BRCA1/2

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8
Q

Which mutations are associated with Li Fraumeni syndrome?

A

TP53

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9
Q

What is the most common cancer subtype of BRCA2 mutations?

A

ER+, HER2-

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10
Q

Which mutations are ER+, HER2- cancers associated with?

A

PIK3CA

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11
Q

What is the precursor lesion for ER+, HER2- cancers?

A

Flat epithelial atypia and atpical ductal hyperplasia

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12
Q

What is the most common mutation associated with HER2+ cancers?

A

TP53

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13
Q

What is the most common type of mutation associated with ER-, HER2- cancers?

A

BRCA1

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14
Q

African American women have an increased frequency of which subtype of breast cancer?

A

ER-, HER2-

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15
Q

Def: malignant clonal proliferation of epithelial cells limited to ducts and lobules by the basement membrane with preserved myoepithelial cells

A

CIS

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16
Q

Morph: clustered or linear and branching areas of calcification defined by tumor cells with pleomorphic high-grade nuclei and areas of central necrosis

A

Comedo CIS

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17
Q

Morph: cribriform pattern (cookie cutter) with central necrosis and no high-grade nuclei

A

Non-Comedo CIS

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18
Q

Morph: malignant cells extend from DCIS within the ductal system and into the nipple skin without crossing the basement membrane

A

Paget disease

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19
Q

Def: clonal proliferation of cells within lobules that grow in a discohesive fashion due to acquired loss of tumor suppressive adhesion via E-cadherin

A

Lobular CIS

20
Q

Morph: mucin-positive signet-ring cells with lack of E-cadherin and expression of ER/PR

A

LCIS

21
Q

Most breast cancers of older women and men are which type of invasive carcinomas?

A

ER+, HER2-

Low proliferation

22
Q

Most common type of BRCA2 associated invasive carcinomas?

A

ER+, HER2-

High proliferation

23
Q

Morph: hard, irregular radiodens masses with desmoplastic stromal rxns and retraction of the nipple that makes a grating sound when cut/scraped

A

ER+, HER2 - breast carcinoma

24
Q

Which subtype of invasive breast carcinoma is more common in young, non-white women and has TP53 mutations?

A

HER2+

25
Q

Morph: well-differentiated invasive breast carcinomas

A

HER2+

26
Q

Which subtype of invasive breast carcinoma is more common in AA/Hispanic women and young pre-menopausal women?

A

ER-, HER2- (triple negative)

27
Q

Which subtype of invasive breast cancer is more likely to appear in between mammogram appointments?

A

ER-, HER2- (triple negative)

28
Q

Morph: poorly differentiated invasive breast carcinoma with very limited/absent DCIS

A

ER-, HER2- (triple negative)

29
Q

Def: b/l loss of CDH1 and failure to incited a desmoplastic response

A

Lobular carcinoma

30
Q

Lobular carcinoma is associated with an increased risk in which other carcinomas?

A

Gastric signet-ring cell carcinomas

31
Q

Morph: hard, irregular masses difficult to palpate with discohesive infiltrating tumor cells including signet-ring cells with intracytoplasmic mucin droplets

A

Lobular carcinoma

32
Q

Morph: softer than any other carcinomas and presents as well-circumscribed mass

A

Medullary carcinoma

33
Q

Def: anchorage-independent growths with expression of E-cadherin but lacks adhesion to stroma

A

Micropapillary carcinoma

34
Q

Morph: hollow ball of cells that float within intercellular fluid

A

Micropapillary carcinoma

35
Q

Morph: soft, rubbery mass with pale gray-blue gelatinous appearance and circumscribed borders

A

Mucinous carcinoma

36
Q

Morph: Well-formed tubules with apocrine snouts and calcifications in the lumen

A

Tubular carcinoma

37
Q

Medullary carcinoma has features similar to which subtype of breast carcinoma?

A

BRCA1

38
Q

Morph: mass with true papillae with fronds of fibrovascular tissue lined by tumor cells that overexpress HER2

A

Papillary carcinoma

39
Q

Morph: well-circumscribed, rubbery, grayish white nodules that bulge above the surrounding tissue and often contain slit-like spaces

A

Fibroadenoma (stromal tumor)

40
Q

Morph: bulbous protrusions with higher cellularity, mitotic rate, nuclear pleomorphism, stromal overgrowth, and infiltrative borders than fibroadenomas

A

Phyllodes tumor

41
Q

Which type of tumor arises in intralobular stroma in 60-70 yo women with a palpable mass and overexpression of HOXB13?

A

Phyllodes tumor

42
Q

Which breast tumor is the only one equally common in men and women?

A

Myofibroblastoma

43
Q

Sx’s = irregular, infiltrating mass that can involve skin and muscle and is associated with prior trauma/surgery

A

Fibromatosis

44
Q

Most primary Non-Hodgkin lymphomas of the breast are which cell type?

A

B-cells

45
Q

Sx’s = young women with b/l breast involvement who are pregnant or lactating

A

Burkitt Lymphoma

46
Q

Which cancers most commonly mets to the breast?

A

Melanoma

Ovarian cancer

Zak, Endo/Repro 2 (33 decks)

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