Menopausal Hormone Therapy

Question 1

What drugs are progestin therapy drugs

Answer 1

Medroxyprogesterone
Methyltestosterone
Progesterone

Question 2

If a woman has an intact uterus what two hormones must she be on

Answer 2

E and P

Question 3

What are 3 benefits d/t E and P therapy

Answer 3

DM
All Fx’s
Colorectal cancer

Question 4

What are 3 benefits of E only therapy

Answer 4

DM
All Fx’s
Invasive BC

Question 5

What drugs are in the SERM class

Answer 5

Ospemifene

Clomiphene

Question 6

What is the indication for use of Ospemifene

Answer 6

Moderate to severe Dyspareunia

Question 7

What is the MOA of Ospemifene

Answer 7

E agonist that binds to ER in vagina, but is also anti-estrogenic on the breast

Question 8

What are the contraindications for Ospemifene

Answer 8

Vaginal bleeding
Thromboembolic disease
E-related neoplasia’s

Question 9

What is the indication for Clomiphene

Answer 9

Anti-E drug for infertility in anovulatory women

Question 10

What is the MOA of Clomiphene

Answer 10

Induction of ovulation in women with anovulatory cycles by blocking inhibitory actions of E on hypothalamus GnRH and pituitary gonadotropin release

Question 11

What are the SE’s of Clomiphene

Answer 11

Multiple births
Ovarian cysts
Blurred vision

Question 12

What drug is a TSEC

Answer 12

Bazedoxifene

Question 13

What is Bazedoxifene indicated for

Answer 13

Tx of moderate to severe vasomotor Sx’s associated with menopause in women WITH a uterus

Question 14

How do SERMs and TSECs compare

Answer 14

SERM + E = TSEC

Question 15

What are 2 benefits of using Bazedoxifene

Answer 15

Prevention of osteoporosis in post-meno WITH uterus

Less vaginal bleeding

Question 16

Bazedoxifene can be used in people who can’t handle _____ because if functions like _____

Answer 16

Progesterone

Progesterone