breast one Flashcards

(44 cards)

1
Q

what is a Supranumerary nipple?

A

an extra nipple that occurs along milk line

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2
Q

most common inflammatory disease of the breast is

A

Acute Mastitis

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3
Q

describe Acute Mastitis

A

common inflammatory disease of the breast, usually affecting women who are lactating and is caused by purulent bacteria, such as Staph or Strept

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4
Q

importance of stagnant milk

A

provides a good growth medium for the bacteria

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5
Q

acute mastitis is marked by infiltration of what?

A

PMNs and other inflammatory cells

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6
Q

treatment of acute mastitis

A

If infection persists, antibiotics may be indicated

If an abscess persists, an incision to relieve the pus is needed.

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7
Q

hemorrhage with central fat necrosis which later forms a nodule of gray-white firm tissue with foci of chalk-white debris describes what?

A

Fat Necrosis of the Breast

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8
Q

Women who have sx’s related to fibrocystic change show improvement after what?

A

menopause

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9
Q

pathogenesis of Fibrocystic Change of the Breast

A

it is related imbalances to sex hormones estrogen and progesterone because they stimulate the proliferation of cells in the excretory ducts of the breast and the intralobular storma

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10
Q

Fibrocystic Changes of the Breast

A

dense fibrosis
cystic dilation of ducts
ductal proliferative changes

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11
Q

what is normal loose intralobular connective tissue is replaced by in Fibrocystic Changes of the Breast

A

dense connective tissue, rich in collagen, unresponsive to hormones

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12
Q

ductal epithelium continues to proliferate because

A

it is still responsiveness to hormones unlike dense connective tissue . The dilated ducts may become entrapped in the dense connective tissue stroma, leading to the formation of cysts

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13
Q

what is Atypical Epithelial Hyperplasia

A

Epithelial hyperplasia becomes multilayered with atypical nuclear change
this is related to the development of carcinoma
more severe and atypical the hyperplasia, the greater the risk

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14
Q

are fibrocystic changes usually limited to one breast?

A

no they usually effect both breast

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15
Q

Benign Tumors of the Breast Fibroadenomas are the most common _____?

A

well encapsulated gray white benign tumors

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16
Q

what are fibroadenomas of the breast composed of

A

composed of two components: fibrous stroma and glandular epithelium.

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17
Q

do fibroadenomas reoccur?

A

no usually

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18
Q

what Presents clinically as a serous or bloody discharge from the nipple

A

intraductal papilloma

19
Q

how to treat Intraductal Papilloma

A

complete excision of the duct

20
Q

more than two Intraductal Papillomas increases risk for

A

papillary carcinomas

21
Q

age for breast cancer

A

35 to peak at 60

22
Q

breast cancer risk factors

A

sex, age, race, genetics, hormonal, presence of other cancer, Premalignant Fibrocystic Changes and Multiple Intraductal Papillomatosis, other causes

23
Q

others causes that may lead to breast cancer

A

obesity high fat diet and moderate alcohol consumption

24
Q

Most malignant breast tumors are of ______ origin

A

epithelial origin and are therefore Carcinomas

25
how do Non-Invasive Intraductal Carcinoma
ductal system
26
old term for non invasive Intraductal Carcinoma
Comedocarcinoma
27
describe Lobular Carcinoma In-Situ
Proliferation in one or more terminal ducts and/or ductules
28
describe Invasive Ductal Carcinoma
An adenocarcinoma that is accompanied by a very strong “Desmoplastic” reaction where the tumor cells infiltrating the tissue are surrounded by dense connective tissue that is produced by the host in response to the tumor. The tumor appears firm and gritty on sectioning
29
which carcinoma shows a strong desmoplastic reaction
Invasive Ductal Carcinoma, causing puckering of the skin and retraction of the nipple
30
Invasive Lobular Carcinoma arise from what
terminal ductules of the acini
31
which carcinomas are rubbery and poorly circumscribed showing no Desmoplasia
Invasive Lobular Carcinoma
32
which carcinomas are known for having solid nests and sheets arranged in concentric rings around normal ducts, called a Targetoid pattern of arrangement
Invasive Lobular Carcinoma
33
but foci of hemorrhage and necrosis are common in which breast cancer
medullary carcinoma
34
soft and gelantinous grossly and histologically consists of large gray-blue lakes of mucin and small islands of neoplastic cells floating inside the mucin describes what
Colloid or Mucinous Carcinoma
35
what disease is ductal carcinoma that forms in the nipple and areolar area, with usually an underlying carcinoma beneath
Paget’s Disease
36
Paget’s Disease clinical presentation
skin of the nipple, causing ulcers, fissures, discharge oozing, along with edema and inflammation surrounding the nipple
37
why is peau d’ orange seen
lymphatics may be obstructed by tumor, causing blockage of skin drainage, causing lymphedema and thickening of the skin
38
how small of a tumor can a mammogram detect
less than .5 cm
39
Radiation therapy is used for patients with ____ cancer
advanced
40
synthetic antiestrogens are used for what
Tamoxifen for Tumors composed of cells that express estrogen receptors
41
stage I
80%, 2.5 cm
42
stage II
65% 2.5 cm to 5 cm | may be lymph node metastasis, but no evidence of distant metastasis
43
stage III
5 cm can with or without regional lymph node spread, | 40%
44
stage IV
are associated with distant metastasis 10%