Buzz words: Endocrinology Flashcards Preview

Year 3 Medicine > Buzz words: Endocrinology > Flashcards

Flashcards in Buzz words: Endocrinology Deck (38):
1

Centripetal obesity, bruises, darkened
palmar creases, recent onset DM
Syndrome = ectopic ACTH
Disease = pituitary cause
Pseudo = alcoholic cushing’s ↑GGT

Cushing's

2

Polyuria, polydipsia
Pituitary tumour, trauma
Lack of vasopressin ∴replace with
desmopressin

Central diabetes insipidus

3

Hereditary, hypercalcaemia, lithium
Thiazide Diuretic

Nephrogenic DI

4

Assoc. with schizophrenia
Urine osm same with fluid deprivation &
after desmopressin

Psychogenic Polydipsia

5

Generalised weakness, hyporeflexia,
ataxia, lethargy, confusion
Hyponatraemia, high urine osm, hypoosmolality
(Opposite of DI)

SIADH

6

Isolated hypogonadotrophic
hypogonadism
Anosmia/hyposmia, colour blindness, cleft
palate

Kallmann’s Syndrome

7

Course features, widely spaced teeth,
rings stuck on fingers, slanting forehead,
protruding jaw
Growth hormone-secreting pituitary
tumour

Acromegaly

8

Adrenal insufficiency
GI disturbance, weight loss, postural htn
High K and low Na (lack aldosterone)

Addison’s Disease

9

Aldosterone-producing adenoma
Low K, high Na, high HCO3
High aldosterone, low renin
Metabolic alkalosis

Conn’s Syndrome

10

Parathyroid tumour
Pitutary adenoma
Pancreatic tumour (Zollinger-Ellison
Syndrome)

MEN1 (3 Ps)

11

Phaeochromocytoma
Amyloid-producing thyroid tumour
Primary hyperparathyroidism

MEN 2a (2Ps, 1T)

12

Phaeochromocytoma, amyloid-producing thyroid tumour, Marfan’s syndrome, organ fibrosis

MEN 2b

13

Insomnia, palpitations, weight loss,
increased appetite

Hyperthyroidism

14

Exopthalmos, pretibial myxoedema
Autoimmune à stimulation of TSH-R

Grave’s Disease

15

Exopthalmos, pretibial myxoedema
Autoimmune à stimulation of TSH-R

Grave’s Disease

16

Exopthalmos, pretibial myxoedema

Grave’s Disease

17

Weight gain, lethargy, constipation
Most common cause of hypothyroidism in
western world
Diffusely enlarged thyroid
Anti-thyroglobulin, anti-microsomal, antithyroid
peroxidease, anti-TSH-R

Hashimoto’s

18

Flu-like illness (influenza, coxsacchie,
mumps) à inflammation and T3/4 release
Hyperthyroid à hypothyroid à euthyroid
Pain worse with swallowing, fever
↑ESR

De Quervain’s Thyroiditis

19

Slow growing, hard, immobile, enlarged
Biopsy: fibrotic tissue
Difficulty breathing and swallowing

Riedel’s Thyroiditis

20

Rare, elderly, die within 1 year
Hard, rapidly enlarging
Fixed to skin

Anaplastic Carcinoma

21

Adolescents and young adults
Orphan Annie Eyes, psammoma (sandy)
bodies
Lymphadenopathy

Papillary Carcinoma

22

Middle aged
Spread to lung/bone

Follicular Carcinoma

23

Calcitonin tumour marker
MEN2

Medullary Carcinoma

24

Lumpy, irregular thyroid
Plummer’s syndrome
Autonomous hyperfunctioning nodules

Toxic Multinodular Goitre

25

Enlarged thyroid
Iodine deficiency/pregnancy/puberty

Simple Colloid Goitre

26

Bones, stones, moans, groans
Polyuria, polydipsia
↑PTH

1° Hyperparathyroidism

27

Bones, moans, stones, groans
Hyperparathyroidism, malignancy, vitamin
D intoxication or sarcoidosis

Hypercalcaemia

28

CKD, parathyroid failure, DiGeorge
syndrome, post-thyroidectomy,
hypomagnesaemia

Hypocalcaemia

29

Target cell resistance to PTH
Low Ca and high PTH

Pseudohypoparathyroidism

30

Trousseau’s sign (BP cuff)
Weakness, cramps
Chvostek’s sign (face twitch)

Hypoparathyroidism

31

Low serum Ca
CKD

2° Hyperparathyroidism

32

Prolonged 2° hyperparathyroidism
Loss of feedback --> hypercalcaemia

3° Hyperparathyroidism

33

Lung Ca --> ectopic PTH secretion
Hypercalcaemia + bone breakdown

PTHRP Secretion

34

Ischaemic necrosis of pituitary (postpartum)
Hypopituitarism e.g. amenorrhoea

Sheehan’s Syndrome

35

Bilateral adrenalectomy + Cushing’s

Nelson’s Syndrome

36

Weight loss, fatigue, polyuria, polydipsia
Pear-drop breath
Ketoacidosis + kussmal breathing

T1DM

37

Hyperglycaemia, ketoacidosis, ketonuria
Dehydration, confusion, abdo pain
Nausea, vomiting, sweet-smelling breath

DKA

38

Neuroglycopenia --> irritable, tired, drowsy

Hypoglycaemia