Buzz words: Haemotology Flashcards Preview

Year 3 Medicine > Buzz words: Haemotology > Flashcards

Flashcards in Buzz words: Haemotology Deck (38):
1

Tired, SOB, conjunctival pallor
Tachycardia + flow murmur
Coeliac/Crohn’s/GI bleed/menorrhagia

Anaemia

2

Microcytic anaemia
2α = trait, 3α = HbH disease
2β = transfusion dependent
Desferioxamine for chelation
Hepatosplenomegaly, jaw protrusion, big
forehead, “hair on end” XR

Thallasaemia

3

Coeliac/alcohol/hypothyroid/drugs
Pernicious anaemia
Anti-IF/anti-parietal cells
Macrocytic anaemia
Schilling test
Mac. Anaemia + neuro signs = phenytoin
toxicity

B12/Folate Deficiency

4

Hypersegmented neutrophils +
erythroblasts

Megaloblastic Anaemia

5

Jaundice + anaemia

Haemolytic Anaemia

6

African/Afro-caribbean
Symptoms at altitude/hypoxia

Sickle Cell

7

Osmotic fragility test +ve
Spherocytes on film
Splenomegaly

Hereditary Spherocytosis

8

X-linked recessive
Moth balls/fava beans/nitrofurantoin/antimalarials,
infection = triggers
Heinz bodies

G6PD Deficiency

9

Coomb’s test/DAT
Cold-activated = mycoplasma
Warm-activated = CML/lymphoma/SLE

Autoimmune Haemolytic

10

Donalth-Landsteiner Test

Paroxysmal cold
haemoglobinuria

11

Paroxysmal Nocturnal
haemoglobinuria

Ham’s test

12

E-coli --> blood cell haemolysis

Haemolytic Uraemic Syndrome

13

Clots, low platelets, rash

Thrombotic Thrombocytopenic Purpura

14

Septic/post-natal/vascular insult
Low fibrinogen + clots

DIC

15

Chronic disease/liver disease
Blood loss

Normocytic Anaemia

16

Rheumatoid arthritis
Cancer
Chronic inflammation

Anaemia of Chronic Disease

17

Pancytopenia
Hypocellular BM
Absent reticulocytes

Aplastic Anaemia

18

Uncontrolled RBC proliferation
Headaches, dizziness and stroke
Lots of mast cells à pruritis after hot
showers
Gout, splenomegaly, plethora

Polycythaemia Rubra Vera

19

Excessive RBC production due to other
disease (COPD/EPO-secreting tumour)

Secondary Polycythaemia

20

Randomly high RBCs, risk of AML

Idiopathic Erythrocytosis

21

Platelets >600, hypercoagulable
Nosebleeds, GI/hum bleeding

Essential Thrombocytaemia

22

Menorrhagia + nosebleeds + purpura

Idiopathic Thrombocytopenic Purpura

23

Children, lymphadenopathy
↑infections, anaemia, BLAST cells

ALL

24

Adults, RARA-PML protein
AUER RODS
Sudan Black

AML

25

Treat with vitamin A

APML

26

Incidental finding, ↑WCC
SMEAR cells

CLL

27

25-40 years, Blast cells
PHILADELPHIA chromosome
Imatinib

CML

28

Continuous spread, painful after EtOH
Lymphadenopathy, hepatosplenomegaly,
Infection, bleeding, anaemia
ABVD chemotherapy
REED-STERNBERG/OWL cells

Hogkin’s Lymphoma

29

Non-continuous spread
Burkitt’s --> mass on jaw, black pt
RCHOP chemo

Non-Hodgkin’s Lymphoma

30

Plasma cell, lack of AB production,
pathological fractures + backache

Myeloma

31

A: factor 8, B: factor 9
X-linked (males only)

Haemophilia

32

Excessive bleeding
Loss of VWF

Von Willebrand Disease

33

Liver disease
Pancreatic insufficiency

Vitamin K Deficiency

34

5% Caucasians
DVT

Factor V Leiden

35

4x increased clot risk

Blood Group O

36

GLPIb deficiency
Bleeding gums, epistaxis, menorrhagia

Bernard Soulier Syndrome

37

GLPIIb/IIIa deficiency
Bleeding gums, epistaxis, menorrhagia

Glanzmann’s Thrombaesthenia

38

Multiple miscarriage
Arterial and venous thrombosis

Antiphospholipid Syndrome