Can we manipulate the stimulus and the environment with which the muscle is contracting, in order to improve metabolic stress and adaptation to the exercise bout

Question 1

What can exercise be used to manipulate?

Answer 1

the stimulus or intracellular environment in favour of metabolic stress/adaptations

Question 2

What did De Bock et al (2005) discover?

Answer 2

exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans.

Question 3

What do you see if you undertake endurance exercise in a carb fasted state?

Answer 3

-reduction in the immediate post-exercise and 4 hours recovery in the amount of lipid in the muscle

Question 4

What effect does exercise in the fasted state have on AMPK phosphorylation?

Answer 4

Increase

Question 5

What do we get close to depleting when we exercise without feed?

Answer 5

Glycogen

Question 6

What does endurance training with low glycogen lead to?

Answer 6

Elevated mitochondrial enzyme activity

Question 6

What does endurance exercise with low glycogen lead to the increased utilisation of?

Answer 6

free fatty acids

Question 7

What is the consequence of glycogen being depleted and mitochondrial gene expression is increased?

Answer 7

we tend to use more fat during the exercise bout

Question 8

What senses the reductions in glycogen and mediates mitochondria adaptations?

Answer 8

AMPK

Question 9

What is ACC?

Answer 9

AMPK substrate that can give a measure of AMPK

Question 10

What factor of the exercise correlates with AMPK activity and ACC phosphorylation?

Answer 10

Exercise intensity