Cancer Flashcards Preview

BIOL 141 > Cancer > Flashcards

Flashcards in Cancer Deck (14):
1

Hallmarks of cancer

self sufficient in division and growth

avoid apoptosis

do not respond to inhibit signals

2

angiogenesis

tumors develop blood vessels to feed themselves

3

metasasis

cancer cells are able to leave their site of origin

often times, use blood vessels to accomplish this

4

benign tumor

continue to divide, but are not invasive

there is a clear separation

5

malignant tumor

divides and spreads to other tissues

6

How can viruses and bacteria be carcinogens?

They can change DNA which leads to cancer

7

Nucleotide excision repair

a type of DNA repair machinery that works to correct mistakes in DNA that could lead to cancer

8

Oncogenes

develop from a mutated proto-oncogene

contributes to unregulated cell growth

9

Example of oncogenes

RAS, MYC

10

Proto-oncogene

genes that contribute to normal cell growth

11

Tumor supressor genes

slow down cell division

12

Mutated tumor suppressor genes

cells can grow with unregulated division

13

Examples of tumor suppressor genes

retinoblastoma

p53

14

p53

activates genes that trigger apoptosis in times of stress

a tumor suppressor gene

this is the most altered gene in human cancer