Flashcards in Cancer drugs Deck (15):
Vinca Alkaloids work in:
M Stage. They are non-specific.
Vinca Alkaloids examples
Vinblastine, Vincristine, Vinorelbine
Antimetabolites work in:
S stage. They are specific
Alkaloid topoisomerase II inhibitors
Topoisomerase I inhibitors
When cell cycle-specific drugs work
When Cell is diving
Antimetabolite, PO, black nails.
Immunosuppressive and antiinflammatory activity. Stop folic acid supplements, DON’T take Warfarin while in this drug, Leucovorin “rescue” med,
Used to treat a variety of solid tumors and some hematologic malignancies. Testicular, small-cell lung, breast, ovarian, non–small-cell lung cancers, Kaposi’s sarcoma, Acute leukemia
Mitotic Inhibitor, decrease Dig and phenytoin doses, burning brain, hepatotoxic, paralytic ileus.
Cardiotoxic, bronchospasm (premedicate), loose nails,
Topoisomerase Inhibitors (specific)
Does not cross blood brain barrier, It can cause cardiac issues,
Lung CA, testicular
Renal and hepatic impairment
Ovarian, colon small cell lung ca
Do not give filgrastin until 24 hours after dose
NVD (nausea, vomiting, diarrhea.
Hematuria. Hemorrhagic cystitis.
Alkylating Agents (Cyclophosphamide)
Widely used, can cause hemorrhagic cystitis
Protect bladder with Mesna, fluids, PH checks
Cardio and nephrotoxic, myelosupression 7-14 days
N&V 2-4 hours lasting 24
Decreases dig and phenytoin levels
Increases anticoagulant effect
Needs bicarb stand by.