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Flashcards in Carbapenems Deck (12):
1

Carbapenems

greatest spectrum of B lactams, G+, G-, anaerobes

2

What are carbapenems reserved for?

resistant infections

3

What does Cilastatin inhibit?

dehydropeptidase (not B- lactamase) in kidney tubules that metabolize imipenem

4

What does inhibiting dehydropeptidase do?

increases the levels of imipenem and prevents nephrotoxic metabolite

5

Side effects of impipenem?

resists most b lactamase; vomiting ad nausea, increase risk of c. difficile; seizures

6

Merpopenem

not metabolized by dehydropeptidase; fewer seizures

7

Ertapenem

once a day dose

8

Doripenem

injection for complicated UTI and intra abdominal infections
not to be used for any type of pnemonia (increase risk of death/ decrease risk of cure)

9

CARBAPENEM GENERAL USES

- Urinary tract infectionss - Lower respiratory tract infections; Bone, joint & skin infections
Intra-abdominal & gynecological infections, bacterial septicemia

10

Why did cilastatin have to be paired up with Imipenem?

Imipenem couldnt achieve levels sufficient enough in the urinary tract to treat urinary infections because dehydropeptidase would break it down

11

CRKP

deadly; is emerging in long-term care facilities and nursing homes, particularly in patients on ventilators, where elderly are most affected.

12

Overall effect

Seizures