Inflammation- Mesa Flashcards Preview

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Flashcards in Inflammation- Mesa Deck (25):
1

Key player in acute inflammation

neutrophils

2

Stimuli for accute inflammation

necrosis
foreign bodies
infection
immmune reaction

3

Vasuclar changes

cause red color: blood flowing
also cause swollen

4

Exudate

High Protein cells

5

Transudate

low protein cells

6

What helps with adhesion

integrins
secretins

7

Move through wall?

chemoaxis

8

What are 3 ways C3 can complement?

1. C3b can attach to Ca and stimulate inflmmation by attracting more leukocytes
2. C3b can act directly on its own and induce phagocytosis
3. C3b can gather and form MAC for cell lysis

9

Bradykinin

PAIN
smooth muscle constricter not vascular

10

Which chemical mediater pain and fever? clotting?

Prostaglandins

11

Which are mediators are vasodilators?

serotonin
histamine
lipoxins
nitric oxide

12

Which mediators are vasonconstrictors?

Leuokotrienes (maintain blood pressure)

13

What stops cgemotaxis?

lipoxins

14

Granulomatous Inflammation

Crohns disease
histocytes*
giant cells
fivroblasts
lymphs

15

Fibrosis as healing

In order for fibrosis to occur, you need t use connective tissue from ECM, which means you will have to damage ECM

16

Epidermal Growth Factor

made in platelets and macrophages
present in saliva, milk, urine, plasma
acts on keratinocytes
acs on fibroblasts to create granulation

17

T GF alpha

macrophages
hepatocytes
keratinocytes
t cells

18

Which 3 growth factors affect the liver?

EGF
Hepatocyte growth factor
TGF alpha

19

Hepatocyte growth factor

made from mesenchymal cells
prolifer of hepatocytes, endothelium, epithelium

20

Vascular Endothelial

made by mesenchymal
key in promoting granulation
triggered by hypoxia
increase vascular permiability

21

Platelet Derived GF

made in platelets
important for angiogenisis
key in granulation
chemotactic for many cells
mitogenic for fibroblasts (causes fibroblast to divide)

22

Key GF for promoting granulation

VE GF
PD GF

23

Fibroblast GF

chemotactic and mitogenic for fibroblast and keratinocytes
re- epithelialization
angiogenisis (wound)
hematopoiesis
cardiac/ skeletal muscle

24

Transforming GF

inhibits epithelial
macrophages
stimulates progression and migration of fibroblasts
increases collagen formation
helps limit and term inflam responses

25

K GF

made in fibroblasts