Misc. B- lactamase Flashcards Preview

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Flashcards in Misc. B- lactamase Deck (10):
1

Aztreonam

monobactam
active only against G-
resists most b- lactamase of G-

2

Mechanism of Aztreonam

binds to PBP-3 creating long unstable filamentous bacteria that will lyse

3

IV/ IM Aztreonam

Excreted unchanged in urine - adjust dose for renal failure. Crosses inflamed meninges

4

What is vancomycin used for?

IV for MRSA or non resistant staph if allergic to B- lactamas
not absorbed orally
used for pseudomem colittis

5

Side effects of Vancomycin?

Red man syndrome: flushing of upper body & face, hypotension, tachycardia & shock. MECHANISM: histamine release (a vasodilator)

Ototoxicity (renal failure; permanent)

Nephrotoxicity (can be reversed)

6

Mechanism for vancomycin

binds to d-ala dala terminus and prevents removal of d-ala

7

Telavancin

dervied from vancomysin
also binds to d-ala d-ala (inhibits crosslinking)
disrupts membrane= causes lysis
works against gram positive
SE: NVD, foamy urine, taste disturbance
CAution for preg. teratogenetic (hand or extra finger or something)

8

Oritavancin

3 mechanisms:
- binds stem peptide of peptidoglycan (inhibits poilymerization)
- binds peptide bridging segments- inhibits corsslinking
- disrupts membrane integrity- depolatization cell death
SQ absesses
wait 48 hours befor taking heparin

9

Bacitracin

topical cuts scrapes
nephrotixic
P-P
NAM

10

FOSFOMYCIN

uncomplicated UTIs in women
: Inhibits enolpyruvate transferase blocking the addition of phosphoenolpyruvate to UDP-N-acetylglucosamin