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Flashcards in Cardiac Physiology and ECG Deck (59):
1

What is an ECG?

-electrocardiography -provides a record of the net cardiac electrical activity measured between two points on the body surface as it changes with time -cell-cell propagation of cardiac AP occurs as a result of gap junctions

2

ECG is the primary clinical diagnostic tool for what 3 main things?

-cardiac arrhythmias -myocardial injury -disturbances in heart rate, rhythm, and wave-front propagation

3

what is diastole?

part of the cardiac cycle when the heart refills with blood

4

what is systole?

part of the cardiac cycle when ventricles contract

5

When does ventricular filling occur?

mid to late ventricular diastole (includes atrial systole)

6

what is ventricular systole?

isovolumetric contraction and ejection phase

7

what is the quiescent phase?

isovolumetric relaxation in early ventricular diastole until atrial contraction

8

What are characteristics of the first heart sound?

-S1 or "lub" -AV valves close at the beginning of ventricular contraction; systole

9

what are characteristics of the second heart sound?

-S2 or "dub" -produced by closure of semilunar valves; beginning of ventricular diastole

10

what are specialized (pacemaker) cells?

-cells responsible for the initiation and conduction of electrical signals (APs) through the heart -include SA and AV nodes, bundle of His, bundle branches, and purkinje fibers

11

what are working myocardial cells?

-responsible for contraction and relaxation -majority of the mass of the heart muscle

12

describe the normal activation sequence of the electrical conduction system of the heart

SA node --> atria --> AV node --> His bundle --> Bundle branches --> Purkinje fibers --> ventricles

13

What is the SA node?

normal pacemaker that initiates the AP that is conducted through the heart

14

what is the AV node?

slowly conducting cells that create delay between atrial contraction and ventricular contraction

15

what are purkinje fibers?

specialized for rapid conduction and ensure that all ventricular cells contract at nearly the same instant

16

which cells normally control heart rate?

the electrical activity of the SA nodal cells

17

 

Describe the 5 phases in the time course of the cardiac action potential

 

Phase 0 = upstroke, rapid depolarization
Phase 1 = rapid repolarization following the peak
Phase 2 = depolarized plateau
Phase 3 = rapid repolarization following the plateau
Phase 4 = period between max negativity  
**most cardiac cells only exhibit phase 0-3, whereas pacemaker cells exhibit all phases

 

18

what is automaticity?

property of specialized cardiac cells to spontaneously fire APs

19

cardiac APs are the result of transient changes in what?

-the ionic permeability of the cell membrane -changes are triggered by initial depolarization in pacemaker

20

what is the absolute refractory period?

-working myocardial cells cannot be stimulated to fire another AP through most of the AP -precludes summated or tetanic contractions from occuring

21

what is the relative refractory period?

-myocardial cell can fire an AP, but it reqires a greater than normal stimulation to do so

22

in cardiac muscle, how much longer can the presence of a plateau in an AP last compare to in skeletal muscle?

up to 15x longer

23

in phase 0, once a fast-response AP is initiated, what happens to the high sodium permeability?

it is short-lived after initiation

24

what is the depolarization plateau state (phase 2) a result of?

the interactions of a sustained reduction in K+ permeability and a sustained increase in Ca2+ permeability

25

T or F: in pacemakers, there is no fast inward Na+ current, but rather a slower Ca2+ inward current (depolarization)

true

26

what causes repolarization (phase 3) in both fast and slow APs?

increase K+ permeability

27

 

what is the equation for cardiac output?

 

 

CO = (SV)(HR) stroke volume times heart rate stroke volume is calculated by end diastolic volume minus end systolic volume

 

28

what is TPR?

-total peripheral resistance -sum of the resistance of all peripheral vasculature in the circulatory system

29

how is blood pressure calculated?

BP = CO x TPR

30

what two factors can be altered to maintain blood pressure?

cardiac output and/or total peripheral resistance

31

what is the baroreceptor reflex a response to?

-a change in arterial pressure -reaction is to increase or decrease heart rate as needed

32

what is the bainbridge reflex a response to?

-changes in blood volume -protective reflex increases heart rate when there is an increase in atrial pressure

33

what is normal sinus rhythm?

when the SA node is acting as the pacemaker

34

 

what is tachycardia and bradychardia?

 

 

normal heart rate is 60-100 beats/min
-tachycardia - HR > 100 beats/min
-bradycardia - HR < 60 beats/min

 

35

 

if heart rate is > 100 beats/min or < 60 beats/min

 

 

sinus tachycardia and sinus brachycardia

 

36

describe what is happening in this figure

ECG waves and intervals

-P wave: atrial depolarization

-PR interval: atrioventricular conduction

-QRS complex: duration ventricular depolarization

-ST segment: approximate index of ventricular AP plateau; isoelectric

T-wave: ventricular repolarization

QT interval: ventricular AP

37

describe steps 1-8

 

 

1) SA node initiates impulse

2) atrial muscle depolarization

3) atrial contraction

4) depolarization of AV node and common bundle

5) atrial muscle repolarization

6) ventricular muscle depolarization

7) ventricular muscle contraction

8) ventricular muscle repolarization

 

38

who created the ECG?

Dr. Willem Einthoven

39

 

T or F:

conduction through the atria and AV node is fast compared to the His bundle, bundle branches, and purkinje fibers

 

 

false

it is slow

 

40

when does the ECG return to baseline?

when all cells are depolarized (or hyperpolarized)

41

what would happen if all ventricular cells depolarized at once?

there would be no QRS wave

42

name 4 major ECG abnormalities that occur as a result of acute myocardial infarction

1) ST elevation

2) T wave inversion; indicates ischemia

3) exaggerated Q waves

4) ST depression; may also indicate ischemia

43

what is the R-R interval?

-the interval in the ECG that is between ventricular beats

-it is used to calculate HR

-the faster the HR, the shorter the R-R interval

44

how does electrode position effect direction and size of ECG waveform?

-there is an electric dipole caused by the surface charge separation during depolarization and repolarization

-think of leads as dipoles

-when electrode paiirs are oriented parallel to the dipole, the recorded potential difference will be maximal

-dipole will normally travel toward negative end

45

what will happen if the positive recording electrode faces a wave of depolarization?

it will record an upward signal

46

if the positive recording electrode approaches the negative electrode, what will happen?

the deflection will be negative (downard)

47

describe voltage and time scale from an ECG

-each large box is equivalent to 0.5 mV and 0.2 sec

-each large box is subdivided into 5x5 smaller squares such that each small box is equivalent to 0.1 mV and 0.04 sec

48

describe Einthoven's triangle

-it is a 3 bipolar lead ECG

•Lead I: (-) electrode on RA and (+) electrode on LA

•Lead II: (-) electrode on RA and (+) electrode on LL

•Lead III: (-) electrode on LA and (+) electrode on LL

49

what is Einthoven's law?

dipole calculation:

lead I + lead III = lead II

50

what are the 3 types of augmented leads?

•aVR (Augmented Vector Right), is perpendicular to Lead III and looks towards the right upper portion of the heart.

•aVL (Augmented Vector Left) is perpendicular to Lead II and looks towards the left upper portion of the heart.

•aVF (Augmented Vector Feet) is perpendicular to Lead I and looks towards the inferior portion of the heart.

51

what are precordial leads?

-views the horizontal plane of the heart

-includes 6 leads (V1-V6)

52

what are common ECG signs of supraventricular tachycardia?

-atria are abnormally excited and drive the ventricles at a very rapid rate

-QRS complexes may or may not appear normal; P and T waves may be superimposed when the HR is very high

-low BP and dizziness due to insufficient diastolic time for ventricular filling

53

what are common ECG signs for atrial fibrillation?

-irregular heart rhythm

-no clear P waves; cannot determine PR interval

-absence of an isoelectric baseline

-irregular ventricular (R wave) rate

-QRS complexes may be prolonged but do not have to be prolonged

54

what are common ECG signs for first degree AV block?

-P and R waves both present and regular pattern

-PR interval > 0.2 sec

-'marked' first degree block if PR interval >0.3 sec

-this is typically benign

55

what are common ECG signs in type I second degree AV block?

-HR is irregular

-P waves present but not regular

-R waves present but not regular

-PR interval >0.2 sec

-cyclic lengthening and then QRS drops

-can be treated with atropine

56

 

what are common ECG signs in type II second degree AV block?

 

 

-HR is irregular

-P wave present and regular

-R waves present but not regular

-PR interval can be normal, but doesn't have to be (doesn't prolong before the QRS drop)

 

57

what are common ECG signs in third degree AV block?

-HR is irregular

-P waves present and regular

-R waves present but not regular

-dropped QRS's; ex 7 Ps but only 4 Rs

-PR interval irregular

-P not linked to QRS (ventricles and atria contracting at own rates aka ventricular escape)

-ventricular escape may lead to syncope or sudden cardiac death

-needs pacemaker immediately

58

what does the prolongation of the QT interval, or ventricular repolarization, lead to?

-spontaneous ventricular tachyarrhythmias, such as ventricular tachycardia

-can be inherited or aquired

59

what is torsade de pointes?

-arrhythmia associated with patients with long QT syndrome

-form of ventricular tachycardia 

-ECG shows undulation or twisting about baseline

-high risk of sudden cardiac death if sustained; rapidly degenerates into ventricular fibrillation and then hemodynamic collapse