Flashcards in Cardiac Tumors Deck (20):
What is a myxoma?
benign (primary) mesenchymal tumor with a gelatinous appearance and abundant ground substance on histology.
*sporadic= middle aged females
*familial= young males
***What is the most common primary cardiac tumor in adults?
Where do myxomas usually form?
They form a pedunculated mass (grows off a little stalk) in the left atrium if left-sided causing mitral valve stenosis, or can form in the right-side causing syncope, dyspnea, and JVD.
What is a rhabdomyoma?
benign hamartoma (bc this is skeletal muscle tumor) of cardiac muscle that usually arises in the ventricle during the first decade of life. Form spider cells, which have radial cytoplasmic extensions.
What is the most common primary cardiac tumor in CHILDREN?
***With what is rhabdomyoma associated?
****Are metastatic cardiac tumors more or less common than primary cardiac tumors?
more common and reaches the heart via mediastinal lymph nodes (if carcinomas)
What are the common metastases to the heart and where do they go?
breast and lung carcinoma, melanoma, and lymphoma (AIDS related; non-hodgkins). They usually go to the pericardium causing a pericardial effusion.
*kidney carcinoma and choriocarcinoma also (these are exceptions bc they are carcinomas that metastasize via hematogenous route rather than the normal lymphatic route for carcinomas).
**What is Carney's syndrome?
myxoma, adrenocortical nodular dysplasia associated with Cushing's syndrome, Sertoli cell tumor of testis, and fibroadenomas.
What is a cardiac fibroma?
a benign fibrotic tumor that is more often seen in the second decade of life and may be associated with sudden death.
What is Gorlin's syndrome?
increased incidence of basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and cardiac fibroma.
What is Sotos syndrome?
cerebral gigantism and cardiac fibroma.
What is a calcified amorphous tumor of the heart?
nodular deposition of calcium in a background of degenerating blood cell elements and chronic inflammation. Clinical course is benign.
***What is Cardiac MICE?
(he said know this)
Mesothelial/monocytic incidental cardiac excrescences= incidental microscopic findings at the time of cardiac surgery. BENIGN. You will see ribbons of mesothelial cells surrounded by plump histiocytes (stationary macrophage).
What is the worry with cystic tumors of the AV nodal region?
can cause complete heart block. Will see cysts lined by squamous like cells.
What is a papillary fibroelastoma?
small papillary growth that occurs on the surface of the valves or on other endocardial locations. Will see a core of hyalinized hypocellular stroma.
What is paraganglioma?
a rare neuroendocrine neoplasm that causes hypertension and elevated urine catecholamine levels.
Are malignant tumors of the heart rare?
YES, but if they do form they are usually angiosarcomas and form a large mass in the RIGHT atrium.
What sarcomas could be found in the heart?
- Kaposi sarcoma
- Leiomyosarcoma (smooth muscle)
- Rhabdomyosarcoma (skeletal muscle)
*remember sarcomas metastasize via hematogenous route.