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Histology > Cartilage > Flashcards

Flashcards in Cartilage Deck (17):
1

Cartilage Characteristics

1. Amorphous ECM predominates over fibrous ECM
2. Rich in proteoglycans
3. Functions in support and flexibility for sliding of joints, as a shock absorber and growth of long bones
4. Presence declines from fetus to adult

2

Perichondrial Fibroblasts

- in the Perichondrium
- These give rise to chondroblasts which mature into chondrocytes

3

Chondroblast

- Arise from Perichondrial Fibroblasts
- Do not have a territorial matrix

4

Chondrocyte

- Contains territorial matrix
-

5

Chondroclasts

- Reabsorb cartilage
- related to osteoclasts
- Derive from monocytes and have a phagocytic role

6

Proteoglycans

- Major Amorphous Component
- Hyaluronic Acid Filaments (hydrophillic)

7

Papain

- Hydolyzes the proteoglycan moiety of the cartilage matrix

8

Type II Collagen

- Fibrous Component
- Present in all types of cartilage
- Covered over with GAG and proteoglycans
- Type II collagen deposition is associated with differentiation and maturation of cartilage

9

Non Vasularity of Cartilage

1. No Blood supply - channels form fracture planes
2. Diffusion is rate limiting to thickness of cartilage
3. Damage/ loss of cartilage is difficult to regenerate

10

Perichondrium

- All cartilage possess Perichondrium EXCEPT epiphyseal growth plate, fibro and articular cartilage
- Essential for appositional growth
- Provides nutrients
- Sox transcription factors induce differentiation into chondroblast (Sox 9)

11

Appositional Growth

- occurs by differentiation of perichondrial fibroblasts into chondroblasts and chondrocytes

12

Interstitial growth

- occurs by mitosis of existing chondroblasts and chondrocytes
- Occurs in cartilage that lack a perichondrium
- Somatotropin (GH) from anterior pituitary stimulates somatomedin C from liver that stimulates mitosis of chondroblasts and chondrocytes

13

Isogenic nests

- Form by interstitial growth
- Two or more chondroblasts or chondrocytes together.
- Can occur in mature cartilage

14

Osteoarthritis

- Damage of cartilage covering articular surfaces (joints)

15

Hyaline Cartilage

- Contains: Type II collagen, basophilic matrix, and chondrocytes usually arranged in groups
- Prichondrium is present in most places EXCEPT Articular Cartilages and epiphyses
- Located: articular ends of long bones, nose, larynx, trachea, bronci, ventral ends of ribs

16

Elastic Cartilage

- Contains: Type II collagen, and elastic fibers
- Perichondrium is present
- Located: Pinna of ear, walls of auditory canal, auditory tube, epiglottis, Cuneiform cartilage of larynx

17

Fibrocartilage

- Contains: Type I and II collage, acidophilic matrix, condroxytes arranged in PARALLEL rows between bundles of collagen
- Perichondrium absent: Interstitial growth
- Located: intervertebral disks, articular disks, pubic symphysis, insertion of some tendons
- Always associated with dense regular collagenous connective tissue or hyaline cartilage