Flashcards in CBC 2 Deck (17):
bone marrow: sinus spaces?
where mature cells leave the bone marrow and move into blood circulation
bone marrow: composition
clusters of growing blood cells supported by stromal tissues.
location of bone marrow
pelvis, vertebrae, cranium - mandible, ribs, sternum, ends of long bone
blood cell formation
steps of hematopoiesis (3)
amplification, differentiation, renewal of progenitor aka stem cells
ultimately, all blood cell growth begins with?
hematopoietic stem cell in the bone marrow
myeloblast --> mature neutrophil in blood.
immature white cell precursors like promyelocytes, myelocytes, metamyelocytes, N. band
Blasts: what? normal?
most immature of WBCs. blasts in blood are never normal
why would you find blasts in peripheral blood (3)
acute leukemia. acute physiologic stressor like infection, hemorrhage. sick bone marrow like metastatic disease, infection, fibrosis
under conditions of stress/etc bone marrow is stimulated to produce more white blood cells and release immature cell precursors into peripheral blood = left shift
red cell maturation
pronormoblast --> nucleated red cell --> reticulocyte --> erythrocyte
when is marrow stimulated to make more red cells? marrow releases?
when RBCs are lost via bleeding or hemolysis. release of reticulocytes aka immature red blood cells
infections: ___ trigger ___? recruition of ___ from where?
pathogens trigger inflammatory cells to release cytokines and growth factors = recruit WBCs from circulating blood, and from marginal pool of neutrophils to migrate into tissue
in the bone marrow: what do cytokines/growth factors do? which results in?
stimulate WBC proliferation = immature WBCs released into peripheral blood aka a left shift
differential diagnosis for increased neutrophil count
infection (esp bacterial). inflammation. stress reaction (trauma, post op, post MI). necrotic tissue. secondary to meds. diseases affecting bone marrow.