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Flashcards in CBC 2 Deck (17):
1

bone marrow: sinus spaces?

where mature cells leave the bone marrow and move into blood circulation

2

bone marrow: composition

clusters of growing blood cells supported by stromal tissues.

3

location of bone marrow

pelvis, vertebrae, cranium - mandible, ribs, sternum, ends of long bone

4

hematopoiesis: what?

blood cell formation

5

steps of hematopoiesis (3)

amplification, differentiation, renewal of progenitor aka stem cells

6

ultimately, all blood cell growth begins with?

hematopoietic stem cell in the bone marrow

7

neutrophil maturation

myeloblast --> mature neutrophil in blood.

8

myeloids

immature white cell precursors like promyelocytes, myelocytes, metamyelocytes, N. band

9

Blasts: what? normal?

most immature of WBCs. blasts in blood are never normal

10

why would you find blasts in peripheral blood (3)

acute leukemia. acute physiologic stressor like infection, hemorrhage. sick bone marrow like metastatic disease, infection, fibrosis

11

left shift?

under conditions of stress/etc bone marrow is stimulated to produce more white blood cells and release immature cell precursors into peripheral blood = left shift

12

red cell maturation

pronormoblast --> nucleated red cell --> reticulocyte --> erythrocyte

13

when is marrow stimulated to make more red cells? marrow releases?

when RBCs are lost via bleeding or hemolysis. release of reticulocytes aka immature red blood cells

14

infections: ___ trigger ___? recruition of ___ from where?

pathogens trigger inflammatory cells to release cytokines and growth factors = recruit WBCs from circulating blood, and from marginal pool of neutrophils to migrate into tissue

15

in the bone marrow: what do cytokines/growth factors do? which results in?

stimulate WBC proliferation = immature WBCs released into peripheral blood aka a left shift

16

differential diagnosis for increased neutrophil count

infection (esp bacterial). inflammation. stress reaction (trauma, post op, post MI). necrotic tissue. secondary to meds. diseases affecting bone marrow.

17

increased lymphocytes: 3 reasons?

viral infection. stress response (trauma, post op, seizures, etc). lymphoproliferative disorders (cancers)