Flashcards in Hemostasis 3 Deck (21):
pinpoint 1 - 2 mm non blanching red capillary bleeding sites in gravity dependent body areas or pressure points
like petechia but larger > 3 mm in diameter, non blanching
bleeding deeper into the tissue layer, flat sheet usually >1 cm
solid MASS of blood. significant swelling.
von willebrand disease: inheritance? incidence? how common?
autosomal dominant. incidence is 1/100, so it's the most common hereditary bleeding disorder
acquired vs. hereditary: more common?
acquired bleeding disorders way more common than hereditary causes
von willebrand disease: present like?
a platelet or vascular defect: muco-cutaneous bleeding, nosebleeds, but usually mild or asymptomatic
3 other hereditary platelet disorders
bernard soulier syndrome. glanzmann's thrombasthenia. platelet granule abnormalities or secretion defects
bernard soulier syndrome: deficiency of? so problem with?
glycoprotein Ib def = no platelet adhesion. seere bleeding.
glanzmann's thrombasthenia: deficiency of? problem with?
glycoprotein 2b3a def = no platelet aggregation = seer bleeding
platelet granule abnormalities or secretion defects: problem with?
inability to recruit and activate other platelets to amplify platelet adhesion and aggregation
hereditary coagnulation factor disorders: which ones are X linked? autosomal? which factor?
Xlinked: hemophilia A = low 8. hemophilia B = low 9. autosomal recessive: hemophilia C = low 11
clinical presentation of coagulation factor disorders: severity? two things you see?
severity depends on how much residual factor. >5% mild (excess bleeding with trauma), 1-5% moderate (excess bleeding with minor injury), severe <1 % spontaneous bleeding. you see muscle hematomas and joint bleeds.
antiplatelet agents: do what? examples?
inhibit platelet function. aspirin/NSAIDS -| TXA2 generation, clopidogrel, abciximab
anticoagulants: do what? examples
coagulation factor function. warfarin, heparin, also have direct oral anticoagulants
DIC: stands for?
disseminated intravascular coagulopathy
pathological process characterized by the widespread activation of the clotting cascade that results in the formation of blood clots in the small blood vessels throughout the body = you get bleeding and clotting at the same time
DIC: examples of triggers?
severe infection, trauma, cancer, pregnancy complications
DIC: what happens
tissue factor release = systemic activation of coagulation = numerous mini clots that can lead to organ failure, but also cause fibrinolysis and consumption of platelets and coag factor = bleeding
most important clinical "test"?
clinical history: bleeding history, past medical history, medications, family history.