Hemostasis 3 Flashcards Preview

Blood > Hemostasis 3 > Flashcards

Flashcards in Hemostasis 3 Deck (21):
1

petechia

pinpoint 1 - 2 mm non blanching red capillary bleeding sites in gravity dependent body areas or pressure points

2

purpura

like petechia but larger > 3 mm in diameter, non blanching

3

ecchymosis

bleeding deeper into the tissue layer, flat sheet usually >1 cm

4

hematoma

solid MASS of blood. significant swelling.

5

von willebrand disease: inheritance? incidence? how common?

autosomal dominant. incidence is 1/100, so it's the most common hereditary bleeding disorder

6

acquired vs. hereditary: more common?

acquired bleeding disorders way more common than hereditary causes

7

von willebrand disease: present like?

a platelet or vascular defect: muco-cutaneous bleeding, nosebleeds, but usually mild or asymptomatic

8

3 other hereditary platelet disorders

bernard soulier syndrome. glanzmann's thrombasthenia. platelet granule abnormalities or secretion defects

9

bernard soulier syndrome: deficiency of? so problem with?

glycoprotein Ib def = no platelet adhesion. seere bleeding.

10

glanzmann's thrombasthenia: deficiency of? problem with?

glycoprotein 2b3a def = no platelet aggregation = seer bleeding

11

platelet granule abnormalities or secretion defects: problem with?

inability to recruit and activate other platelets to amplify platelet adhesion and aggregation

12

hereditary coagnulation factor disorders: which ones are X linked? autosomal? which factor?

Xlinked: hemophilia A = low 8. hemophilia B = low 9. autosomal recessive: hemophilia C = low 11

13

clinical presentation of coagulation factor disorders: severity? two things you see?

severity depends on how much residual factor. >5% mild (excess bleeding with trauma), 1-5% moderate (excess bleeding with minor injury), severe <1 % spontaneous bleeding. you see muscle hematomas and joint bleeds.

14

antiplatelet agents: do what? examples?

inhibit platelet function. aspirin/NSAIDS -| TXA2 generation, clopidogrel, abciximab

15

anticoagulants: do what? examples

coagulation factor function. warfarin, heparin, also have direct oral anticoagulants

16

DIC: stands for?

disseminated intravascular coagulopathy

17

DIC: def?

pathological process characterized by the widespread activation of the clotting cascade that results in the formation of blood clots in the small blood vessels throughout the body = you get bleeding and clotting at the same time

18

DIC: examples of triggers?

severe infection, trauma, cancer, pregnancy complications

19

DIC: what happens

tissue factor release = systemic activation of coagulation = numerous mini clots that can lead to organ failure, but also cause fibrinolysis and consumption of platelets and coag factor = bleeding

20

most important clinical "test"?

clinical history: bleeding history, past medical history, medications, family history.

21

laboratory evaluation for bleeding disorders?

baseline: CBC with differential, PT/INR, PTT, fibrinogen. then can do special investigations if abnormal baseline or positive bleeding history