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Flashcards in CCB ppt Deck (47)
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31

pharmacology of Non-DHP

Neg inotropic
Neg- chronotropic
Neg-dromotropic
positive- Lusitropic (myocardial relaxation)

32

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what do ALL CCB do pharmacology wise

-decrease coronary vascular resistance and increase coronary blood flow
-Decrease PVR via vasodilation of arterioles
- minimal venous tone effects

33

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which CCB is best for variant angia
eg vasospastic or prinzmetal's angina

Narcardapine

34

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which CCB is good for subarachnoid hemorrhage (posthemoragic cerebrovascular spasm

Nimodipine

35

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which CCB's are good for Hypertrophic cardiomyopathy

Nifidipine
verapamil

36

Common SE of CCB

-orthrostatic hypotension
-bradycardiam(DHP increase HR)
- periphreal edema
- dizziness
headaches
flushing
N/V

37

Verapamil can increase the levels of what drug

Digoxin

38

which CCB is commonly used in the OR Can be given bolus or infusion and what class

Nicardapine
DHP

39

Which CCB is very fast onset off set, faster than nicardapine, prepared in a lipid emulsion, only given in bolus no infusion?

Clevidipine

40

Contraindications to Verapimil

WPW
Sicksinus syndrome
Av block
Heart rate

41

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how do CCB decrease contraction

decrease influx of Ca++ causes decrease in contraction

42

************** basic way Non-DHP work

slow cardiac conduction
decrease HR via SA and AV nodes

43

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basic way DHP work

no effect on conduction
vasodilate
increase HR

44

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what CCB is the greatest coronary vasodilator and can cause coronary steal?

Nicardapine

45

Why are DHP and BB ok to use in combination

DHP incease HR and BB decrease HR

46

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why do Non-DHP slow HR

closes the Ca++ channels in phase 4 thus decreasing hr
so it basically blocks the conduction and prolongs the time it takes to reah the threshold

47

If HR is 45 and B/P is 210/105 what drug would you give

DHP like nicardapine or any
if has no effect on HR and will decrease BP