cell cycle & cancer - exam 2 Flashcards
checkpoints
regulatory molecules at each checkpoint “decide” if division should proceed
G1 checkpoint
is growth factor present
is cell big enough
is dna undamaged
G2 checkpoint
is dna replication complete
is dna intact
M checkpoint
are chromosomes attached to kinetochore MTs
normal cell division
cell cycle control working correctly
problem –> fixed –> cell continues dividing
problem –> not fixed –> apoptosis
apoptosis
cell suicide pathway
unregulated cell division
problem –> not fixed –> goes past checkpoint anyway
proliferating cancer cells form a tumor - cells can be immortal
properties of normal cells
cells start & stop reproducing at the right time
each growth factor has a specific receptor
exhibit anchorage dependence & contact inhibition
anchorage dependence
cells need to be anchored to something to divide
cells can be adhered to other cells, extracellular matrix, or tissue culture
contact inhibition
crowded cells stop dividing
properties of cancer cells
cells divide w/ no growth factor
cells ignore contact inhibition
cells ignore anchorage dependence
signal transduction
needs specific shape to bind, sends message, & eventually you get a response
external, internal, external
reception
signal binds to receptor
receptor is activated
receptor changes shape
transduction
stimulates relay molecules (different proteins)
response
activation of cellular response
regulation of cell cycle