Cellular Responses to Stress & Inflammation

Question 1

initiator caspases

Answer 1

intrinsic: caspase 9
extrinsic: caspases 8 and 10

Question 2

executioner caspases

Answer 2

caspases 3 and 6

Question 3

Russell bodies

Answer 3

multiple myeloma

Question 4

PAS (+) diastase resistant

Answer 4

a1-antitrypsin def

Question 5

PAS (+) diastase sensitive

Answer 5

DM

Question 6

Homogentisic acid

Answer 6

alkaptonuria

Question 7

dystrophic vs metastatic calcification

Answer 7

metastatic: inc serum Ca

Question 8

5 cardinal signs of inflammation

Answer 8

Rubor (redness) 
Calor (warmth) 
Dolor (pain) 
Tumor (swelling) 
Functio Laesa (loss of function)

Question 9

5 steps of recruitment of leukocytes to sites of inflammation

Answer 9

margination 
rolling 
adhesion 
transmigration (diapedesis) 
migration in the tissues toward a chemotactic stimulus

Question 10

adhesion molecule

Answer 10

CD31/ PECAM-1

Question 11

anti inflammatory cytokines

Answer 11

lipoxin, TGF-B, IL-10

Question 12

causes VD. inh platelet aggregation

Answer 12

prostacyclin

PGI2

Question 13

causes VC, promotes platelet agg

Answer 13

thromboxane A2

TXA2

Question 14

causes VD,

inc vasc permeability

Answer 14

PGD2, PGE2

Question 15

most abundant complement component

Answer 15

C1

Question 16

def in late complement components

Answer 16

susceptibility to N. meningitidis infections

Question 17

non-caseating granulomas commonly seen in

Answer 17

sarcoidosis and crohn’s disease

Question 18

inc APR (CRP, fibrinogen and serum amyloid A)

Answer 18

IL-6

Question 19

MI cytokine for synthesis and deposition of CT

Answer 19

TGF B