Hema Flashcards
(20 cards)
t(12,21) is associated with?
B-ALL
better prognosis
Needle-like azurophilic granules associated with Acute Promylelocytic Leukemia
Auer rods
3 danger signs of CML (hematologic findings)
- increasing blast counts
- dec platelet counts
- inc basophil counts
What differentiates CML from leukemoid reaction?
LOW leukocyte alkaline phosphatase (LAP)
Reed-Sternberg cells and mixed inflammatory cell inflitrate are associated with?
HL
Subtype of HL that is NOT classic
Lymphocyte-predominant (based on immunophenotype) CD15 (-), CD 30 (-) CD 20 (+)
Most common HL subtype
Nodular sclerosis
Most common indolent lymphoma of adults
Follicular lymphoma
Most common form of NHL
Diffuse large B-cell lymphoma
Most common lymphoma of adults
Diffuse large B-cell lymphoma
Associate with starry-sky histologic pattern
Burkitt lymphoma
Burkitt lymphoma mutation
MYC t(8,14)
Associated with Pautrier microabscesses
Mycoses fungoides/ Cutaneous T-cell lymphoma
Associated with Sezary syndrome
Mycoses fungoides/ Cutaneous T-cell lymphoma
Multiple lytic “punched-out” bone lesions
Multiple Myeloma
All intrinsic HA exhibit extravascular hemolysis EXCEPT
PNH (Paroxysmal Nocturnal Hemoglobinuria)
Mutation of sickle cell anemia
Mutation on 6th codon of B-globin gene
glutamate -> valine
Crew cut appearance of skull sec to extramedullary hematopoiesis
Beta thalassemia
Differentiate HUS syndrome from TTP
HUS:
- Microangiopathic hemolytic anemia
- Thrombocytopenia
- Renal Failure
TTP:
Same as above +
4. Fever
5. Neurologic manifestations
Pathognomonic of Langerhans Cell Histiocytosis in electron microscopy
Birbeck granules
