CNS Flashcards
(26 cards)
Sum of CSF, brain tissue and blood is constant
Monroe-Kellie doctrine
Cowdry Type A inclusion bodies
HSV
Periventricular Necrosis and calcification
CMV
Neuronophagia of the anterior-horn motor neurons
Poliomyelitis
Microglial nodules
HIV
Central foci of necrosis, ring-enhancing lesions
Toxoplasma
Soap bubbles appearance
Cryptococcus
Most common demyelinating DO
Multiple sclerosis
Common initial manifestation of multiple sclerosis
unilateral involvement of optic nerve
Charcot triad of multiple sclerosis:
nystagmus, intention tremor, scanning speech
CSF finding: mod pleocytosis, mildly elevated protein, inc IgG (oligoclonal)
Multiple sclerosis
AB, Tau
Alzheimer dse
Tau, a-synuclein
Parkinson dse
polyglutamine aggregates
Huntington dse
TPD-43, FUS
ALS
GAA Trinucleotide repeat expansion
Friedrich ataxia
Mnemonics for Wernicke Encephalopathy
ACO
ataxia, confusion, ophthalmoplegia
Mnemonics: Korsakoff syndrome
CHO
confabulations, hallucinations, amnesia
Most common brain tumor in children
infratentorial
Most common brain tumor in adults
supratentorial
Most common brain tumor
metastases
Most common primary brain tumor
Gliomas
Location of astrocytoma in children/adults
Children: cerebellum
Adults: cerebral cortex
Locatioon of ependymoma in 1st two decades/adults
1st two decades: near 4th ventricle
Adults: spinal cord