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Flashcards in CH 4 Pharmacodynamics Deck (17)
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1

Drug that activates a receptor and produces the same type of response as the endogenous substance:

Agonist

2

Agent that blocks the response of another drug:

Antagonist

3

The way a patient responds to varying doses of a drug:

Dose-response relationship

4

The maximal response that can be produced from a particular drug:

Efficacy

5

A graphic representation of the actual number of patients responding to a particular drug action at different doses:

Frequency distribution curve

6

The ability of a drug to bind to a receptor and produce a strong action:

Intrinsic activity

7

The amount of drug that is lethal to 1% of animals (LD1) divided by the amount of drug that produces a therapeutic effect in 99% of the animals (ED99):

Margin of safety (MOS)

8

The dose of a drug required to produce a specific therapeutic response in 50% of a group of patients:

Median effective dose (ED50)

9

The dose of a drug that will kill 50% of a group of animals:

Median lethal dose (LD50)

10

The dose that will produce a given toxicity in 50% of a group of patients:

Median toxicity dose (TD50)

11

Medication that produces a weaker, or less efficacious, response than an agonist:

Partial agonist

12

Study of the mechanisms of drug action and how the body responds to drugs:

Pharmacodynamics

13

The study of genetic variations that alter patients' responses to medications; branch of pharmacology that examines the role of genetics in drug response:

Pharmacogenetics

14

The strength of a drug at a specified concentration or dose:

Potency

15

Cellular molecule to which a drug binds to produce its effects:

Receptor

16

Cascade of biochemical events that initiates a drug's action by either stimulating or inhibiting a normal activity of the cell:

Second messenger

17

The ratio of a drug's LD50 to its ED50:

Therapeutic index (TI)