Chap 38 Coagulation Flashcards Preview

Vascular Surgery > Chap 38 Coagulation > Flashcards

Flashcards in Chap 38 Coagulation Deck (17):
1

List naturally occurring thrombophilias.

ATIII deficiency
Protein C deficiency
Protein S deficiency
Factov V Leiden
Prothrombin mutation G20210A
hyperhomocyteniemia

2

What are the most congenital thrombophilias?

Protein S deficiency
Factov V Leiden
Prothrombin mutation G20210A
hyperhomocyteniemia

3

What are acquired thrombophilias?

antiphospholipid antibody syndrome
cancer
pregnancy
OCP
HIT

4

What are the types of ATIII deficiency?

Type I decrease ATIII functional activity and antigen
Type II reduce ATIII functional activity and normal antigens
Type III moderate decrease activity due to impaired interaction with heparin

5

What is treatment for ATIII deficiency?

ATIII concentrates
Anticoagulation
FFP

6

What are the most common mutation for people with VTE?

Factor V leiden
Prothrombin mutation G20210A

7

What are the most common mutation for people with VTE?

Factor V leiden
Prothrombin mutation G20210A

8

What is HIT?

immune disorder
antibody response against antigens on pot factor 4
IgG antibodies directs against heparin-PF4 complex

9

What is the management of HIT?

stop heparin
alternate anticoagulant (argatroban
no plt trnasfusion
warfarin when pot normalize

10

What are heparin side effects?

bleeding
thrombocytopenia
osteoporosis
elevated transaminases

11

What are heparin side effects?

bleeding
thrombocytopenia
osteoporosis
elevated transaminases

12

What are absolute CI to thromblysis?

active bleeding
CVA, trauma, intraspinal/cranial surgery within 2 months
known intracrainal neoplasm
severe uncontrolled hypertension
uncontrollable clotting disorder
allergy

13

What are causes of DIC?

sepsis
major tissue injury
malignancy

14

How does uraemia lead to coagulopathy?

intrinsic plt defects
alteration of plt-endothelial interaction

15

List different hemostatic agents used in the OR.

gelatin (gelfoam)
oxidized cellulose (surgicel)
microfibrillar collagen (avitene)
polysaccharide spheres (arista)
fibrin sealants (tisseel)
thrombin sealant (floseal)
bovine-derived factors (bioglue gluteraldehyde crosslinked to albumin)

16

List different hemostatic agents used in the OR.

gelatin (gelfoam)
oxidized cellulose (surgicel)
microfibrillar collagen (avitene)
polysaccharide spheres (arista)
fibrin sealants (tisseel)
thrombin sealant (floseal)
bovine-derived factors (bioglue gluteraldehyde crosslinked to albumin)

17

What are mediators of thrombogenicity in cancer?

Firbinogen,
factov VIII
plt count
Tissue factor
Vegf
PAR-2