Drugs Flashcards Preview

Vascular Surgery > Drugs > Flashcards

Flashcards in Drugs Deck (12):
1

What is MOA of ASA?

Binds to plt and prevents thomboxane production, which usually binds plt together

2

What is MOA of plavix?

thienopyridine
Irreversibly dinds to PLT receptor P2Y12 (ADP receptor) on plt cell memebrane
This is important site for plt activation and corss linking

3

Name three thienopyridines.

prasugrel
ticlopidine
clopidogrel

4

What is MOA of IIbIIIa inhibitors?

Inhibit IIbIIIa receptor on plt and prevent plt aggregation and thrombus formation

5

Name three IIbIIIa inhibitors.

Abciximab, eptifibatide, tirofiban

6

What is MOA of ACEi?

Reduce activity of RAAS

Block conversion of AI to AII


7

What is MOA of beta blocker?

Block the endogenous action of catecholamines epi and norepi on adrenergic beta receptors

8

What is MOA of Heparin?

binds to enzyme inhibitor ATII causing conformational change that activates it.

9

What factors does ATIII inhibits.

thrombin
IXa
Xa
XIa
XIIa

10

What is the does for protamine?

1-1.5mg for every 100 IU of heparin

11

What is MOA of protamine?

binds to heparin or LMWH and forms ion pair inactivating heparin

12

What is MOA of dipyridamole?

Inhibits phosphodiesterase enzyme that normally breaks down camp and cGMP

acts as vasoD when administered rapidly at high dose