Chapter 1

Question 1

TF of lymphoid lineage

Answer 1

Ikaros

Question 2

TF for T cell

Answer 2

Notch-1

Question 3

TF for RBC and Platelets

Answer 3

GATA-1

Question 4

TF for granulocytes, macrophages, and DC

Answer 4

PU-1

Question 5

TF for Granulocytes

Answer 5

GATA-2

Question 6

TF for Macrophages

Answer 6

C/EBP alpha

Question 7

Neutrophil

Answer 7

Multilobes, granules, phagosomes, highest cell proportion
Function: 1st responder, phagocytosis

Question 8

Basophil

Answer 8

bi lobed, large granules, blue staining

Question 9

Mast Cell

Answer 9

round nucleus, large granules, stain blue

Question 10

Eosinophil

Answer 10

bi lobed, granules, stain pink
Function: parasites, allergic reactions

Question 11

Monocyte

Answer 11

round nucleus, no granules, immature in circulation

Question 12

Macrophage

Answer 12

round nucleus, large, pseudopodia, phagosomes, lysosomes
Function: APC and phagocytosis

Question 13

Dendritic Cell

Answer 13

round nucleus, processes, phagosomes

Question 14

Th cell

Answer 14

large round nucleus, CD4 + w/ TCR
Binds MHC Class 2 –> Secretes cytokines to draw WBCs

Question 15

Tc cell

Answer 15

large round nucleus, CD8+ w/ TCR
Binds MHC Class 1 –> secretes chemokines to attack cells specifically

Question 16

B cell

Answer 16

large round nucleus, CD 19+ w/ BCR
Matures to Plasma cell = AB production

Question 17

NK cells

Answer 17

no TCR, CD16+ CD161+ kills cells non-specifically, activates APC
kills viral infected cells and host cells

Question 18

CD45

Answer 18

Present on all cells (b, th, tc, nk)

Question 19

CD3

Answer 19

Th and Tc cells

Question 20

CD4

Answer 20

Th cells

Question 21

CD8

Answer 21

Tc cells

Question 22

CD16

Answer 22

NK cells

Question 23

CD19

Answer 23

B cells

Question 24

CD161

Answer 24

NK cells

Question 25

Microglia

Answer 25

Brain Macrophages, prune neural synapses

Question 26

Alveolar Macrophages

Answer 26

Lung, remove pollutants and surfectants

Question 27

Kupffer Cell

Answer 27

Liver macrophage, scavenge RBCs

Question 28

Resident Kidney Macrophage

Answer 28

regulate inflammatory response from kidney filtering

Question 29

Langerhans Cell

Answer 29

Skin Macrophages, skin immunity and tolerance

Question 30

Red pulp macrophage

Answer 30

spleen macrophage, scavenge RBCs

Question 31

Peritoneal Cavity Macrophages

Answer 31

Maintain IgA Production for mucosal protection

Question 32

Lamina propria macrophage

Answer 32

Intestinal macrophage, gut immunity and tolerance

Question 33

bone marrow macrophage

Answer 33

remove old neutrophils, maintain niche for hematopoeisis

Question 34

Subscapular sinus macrophage

Answer 34

lymph node macrophage, trap antigen particles

Question 35

cardiac macrophage

Answer 35

heart, clear dying heart cells

Question 36

Primary lymphoid organs

Answer 36

Bone Marrow and Thymus

Question 37

Bone Marrow

Answer 37

primary hematopoiesis site, Endosteal niche & Perivascular niche

Question 38

Thymus

Answer 38

T cell maturation site, Cortex & Medulla & Cortico Medullary Junction

Question 39

Positive Selection - Thymus

Answer 39

Maturing T cell must moderately bind with thymic cell MHC = survival

Question 40

Negative Selection - Thymus

Answer 40

Maturing T cell binds too tightly with thymic cell MHC = death

Question 41

Secondary Lymphoid Organs

Answer 41

Lymph Nodes and Spleen

Question 42

Lymph Node Structure

Answer 42

Cortex (B Cell follicle and germinal center), Paracortex (T cell zone), Medulla

Question 43

Follicular Reticular Cell System (FRC)

Answer 43

In lymph nodes where T cells are guided to APCs

Question 44

Follicular Dendritic Cell System (FDC)

Answer 44

In lymph nodes where B cells and APCs are guided together

Question 45

Spleen Structure

Answer 45

Scavenge RBCs, White Pulp (PALS - T cells, B cell follicle/germinal center) and Red Pulp

Question 46

Peyers Patches

Answer 46

Gut Associated Lymphoid Tissue (GALT), B cell follicle surrounded by T cell zone