Flashcards in Chapter 12 - Non-steroidal Antiasthma Meds Deck (22)
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1
What is step 2 asthma?
Having episodes more than or equal to 2 times a week
Night episodes more than or equal to 2 times a month
2
What is step 3 asthma?
Has daily asthma attacks
Uses Saba regularly
3
What is step 1 asthma?
Having episodes less than or equal to 2 times a week
Night episodes less than or equal to 2 times a month
Only has exercise induced asthma
4
Arachidonic acid is a precursor to what?
Leukotrienes and prostaglandins
5
Where Do leukotrienes and other lipid mediators come from?
They are not preformed and stored in cells but are made after stimulus activates phospholipase.
6
What are the two main pathways for lipid mediators from aranchidonic acid?
Cyclicoxygenase (COX)
5-LO
7
What do Cox pathways produce?
Prostaglandins and thromboxane
8
What do 5-Lo pathways produce?
Leukotrienes
9
What is the mode of action for zyflo?
5-Lo inhibitor
10
What are the modes of action for zafirlukast and montelukast?
CysLT receptor block
Cysteinyl leukotriene receptor
11
What triggers are antileukotrienes useful at protecting against?
Exercise induced asthma
Asprin induced asthma
Lesser extent (allergen)
12
What is the use of Antileukotrienes in chronic mild to severe asthma?
2 answers (moderate to severe and mild to moderate)
In mild to moderate asthma, it can improve lung function and reduce need for rescue drugs
In moderate to severe
Use with corticosteroids as a additive effect is the basis for asthma control
13
Asthma guidelines agree that
________ are the most effective for anti inflammatory in asthma.
Corticosteroids
14
What is the use for antileukotrienes in persistent asthma?
It may not be optimal as a monotherapy
15
What drug is a monoclonal antibody?
Omalizumab
16
What is the mode of action for monoclonal antibody's?
Blocks the binding of IGE to IGE receptors on the surface of mast cells and basophils
17
Are you allowed to eat food with accolate?
No it should be one hour before meal or two hours after
18
What is the mast cell stabilizing agent?
Cromolyn sodium
19
Cromolyn sodium is best at preventing what during an asthmatic episode?
Late phase responses like submucosal edema, mucus, hyperactivity
20
What are the three components of asthma?
H A P
hyperactivity
Acute asthma attack
Persistent inflammation
21
What group of drugs are used as relievers in asthma?
SABA
systemic corticosteroids
Inhaled anticholinergics
22
