Chapter 12 - Non-steroidal Antiasthma Meds Flashcards Preview

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Flashcards in Chapter 12 - Non-steroidal Antiasthma Meds Deck (22)
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1

What is step 2 asthma?

Having episodes more than or equal to 2 times a week

Night episodes more than or equal to 2 times a month

2

What is step 3 asthma?

Has daily asthma attacks

Uses Saba regularly

3

What is step 1 asthma?

Having episodes less than or equal to 2 times a week

Night episodes less than or equal to 2 times a month

Only has exercise induced asthma

4

Arachidonic acid is a precursor to what?

Leukotrienes and prostaglandins

5

Where Do leukotrienes and other lipid mediators come from?

They are not preformed and stored in cells but are made after stimulus activates phospholipase.

6

What are the two main pathways for lipid mediators from aranchidonic acid?

Cyclicoxygenase (COX)

5-LO

7

What do Cox pathways produce?

Prostaglandins and thromboxane

8

What do 5-Lo pathways produce?

Leukotrienes

9

What is the mode of action for zyflo?

5-Lo inhibitor

10

What are the modes of action for zafirlukast and montelukast?

CysLT receptor block

Cysteinyl leukotriene receptor

11

What triggers are antileukotrienes useful at protecting against?

Exercise induced asthma
Asprin induced asthma

Lesser extent (allergen)

12

What is the use of Antileukotrienes in chronic mild to severe asthma?

2 answers (moderate to severe and mild to moderate)

In mild to moderate asthma, it can improve lung function and reduce need for rescue drugs

In moderate to severe
Use with corticosteroids as a additive effect is the basis for asthma control

13

Asthma guidelines agree that
________ are the most effective for anti inflammatory in asthma.

Corticosteroids

14

What is the use for antileukotrienes in persistent asthma?

It may not be optimal as a monotherapy

15

What drug is a monoclonal antibody?

Omalizumab

16

What is the mode of action for monoclonal antibody's?

Blocks the binding of IGE to IGE receptors on the surface of mast cells and basophils

17

Are you allowed to eat food with accolate?

No it should be one hour before meal or two hours after

18

What is the mast cell stabilizing agent?

Cromolyn sodium

19

Cromolyn sodium is best at preventing what during an asthmatic episode?

Late phase responses like submucosal edema, mucus, hyperactivity

20

What are the three components of asthma?

H A P
hyperactivity

Acute asthma attack

Persistent inflammation

21

What group of drugs are used as relievers in asthma?

SABA

systemic corticosteroids

Inhaled anticholinergics

22

What group of drugs are used as controllers in relief of asthma?

corticosteroids

Nonsteroidal anti-asthma agents

LABA

Theophylline