Chapter 12 - Non-steroidal Antiasthma Meds Flashcards
(22 cards)
What is step 2 asthma?
Having episodes more than or equal to 2 times a week
Night episodes more than or equal to 2 times a month
What is step 3 asthma?
Has daily asthma attacks
Uses Saba regularly
What is step 1 asthma?
Having episodes less than or equal to 2 times a week
Night episodes less than or equal to 2 times a month
Only has exercise induced asthma
Arachidonic acid is a precursor to what?
Leukotrienes and prostaglandins
Where Do leukotrienes and other lipid mediators come from?
They are not preformed and stored in cells but are made after stimulus activates phospholipase.
What are the two main pathways for lipid mediators from aranchidonic acid?
Cyclicoxygenase (COX)
5-LO
What do Cox pathways produce?
Prostaglandins and thromboxane
What do 5-Lo pathways produce?
Leukotrienes
What is the mode of action for zyflo?
5-Lo inhibitor
What are the modes of action for zafirlukast and montelukast?
CysLT receptor block
Cysteinyl leukotriene receptor
What triggers are antileukotrienes useful at protecting against?
Exercise induced asthma
Asprin induced asthma
Lesser extent (allergen)
What is the use of Antileukotrienes in chronic mild to severe asthma?
2 answers (moderate to severe and mild to moderate)
In mild to moderate asthma, it can improve lung function and reduce need for rescue drugs
In moderate to severe
Use with corticosteroids as a additive effect is the basis for asthma control
Asthma guidelines agree that
________ are the most effective for anti inflammatory in asthma.
Corticosteroids
What is the use for antileukotrienes in persistent asthma?
It may not be optimal as a monotherapy
What drug is a monoclonal antibody?
Omalizumab
What is the mode of action for monoclonal antibody’s?
Blocks the binding of IGE to IGE receptors on the surface of mast cells and basophils
Are you allowed to eat food with accolate?
No it should be one hour before meal or two hours after
What is the mast cell stabilizing agent?
Cromolyn sodium
Cromolyn sodium is best at preventing what during an asthmatic episode?
Late phase responses like submucosal edema, mucus, hyperactivity
What are the three components of asthma?
H A P
hyperactivity
Acute asthma attack
Persistent inflammation
What group of drugs are used as relievers in asthma?
SABA
systemic corticosteroids
Inhaled anticholinergics
What group of drugs are used as controllers in relief of asthma?
corticosteroids
Nonsteroidal anti-asthma agents
LABA
Theophylline
