Flashcards in Chapter 3 Pharm Deck (18)
What a cascade impactor?
Device that uses multiple steps to determine size of aerosol particles
What are CFCs?
What are they used for?
-for propellants in mdi
What is a dead volume?
Amount of solution that remains in the reservoir of a small volume nebulizer
What is deposition?
Process of particles depositing out of suspension to remain in lung
What is heterodisperse
Refers to the size of particles in aerosol. Particles having different sizes
What is Hydrofluoroalkane?
Nontoxic liquified gas propellant use to administer medication
What is in vitro?
Tested in a lab
What is in vivo?
Testing done on animals or humans
What is monodisperse
In reference to the size of particles in Aerosol, all of them the same size
What is poly disperse?
In reference to the size of aerosol particles, meaning many different particle sizes
What is a reservoir device?
Global term describing referring to extension to an MDI
What is a spacer
Simple tube device with no one-way valves to contain aerosol cloud
What is stability?
Describing the tendency of aerosol particles to remain in suspension
What is a MMAD size?
Mass median aerodynamic diameter
What are advantages of aerosolized drug admin?
-smaller side effects
-lung provides portal to body intended for systemic effects
What are the disadvantages to aerosolized meds?
-variables can effect dosages
-inconsistent dose reproducibility
-patients can have difficulty with coordination
-lack of knowledge for nurses and doctor
-standardized technical info is lacking
-multiple device types can be confusing to patients and staff
What is fine particle fraction or dose?
The size the particle should be for the best chance of reaching the lower respiratory tract.