Chapter 9 - Mucus Drugs Flashcards Preview

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Flashcards in Chapter 9 - Mucus Drugs Deck (39)
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1

What are the surface epithelial cells of the mucociliary system?

Pseudo stratified columnar Ciliated
Goblet cells
Clara cells

2

What are the cells in the submucosal layer?

Serous
Mucous

3

What sputum composed of?

Mixed inflammatory cells
Cellular debris
Bacteria

4

What drugs are called mucoregulatory medications?

-corticosteroids
-indomethacin
-macrolide antibiotics
-anti-cholinergic agents

5

What are mucoregulatory drugs useful in?

Broncorrhea associated with airway inflammation.
-decreased hypersecretion

6

What are some therapeutic options for hypersecretion?

Remove causative factors
Optimize clearance(bronchodilators/coughing)
Use mucoactive agents when indicated

7

What is mucomyst used for?
2 things

-Mucolytic
-acetaminophen OD

8

What is the mode of action for mucomyst?

Disrupts Di-sulfide bonds

9

What's a hazard of mucomyst?

Bronchodpasms

10

What are some secondary complications of mucomyst?

NSR
Nausea
Rhinorrhea
Stomatitis

11

What are you not allowed to mix with NAC?

Antifungals
Antibiotics

12

What is dornase Alfa used for?

-Mucoactive agent for CF pts and to preserve or improve their LUNG FUNCTION
-to reduce respiratory infections that require paraenteral antibiotics

13

What does dornase Alfa do to non-CF airways diseases?

No efficacy

14

What is the mode of action of Dornase alfa?

Decreases viscocity and adhesivity
-decreases DNA of sputum

15

What are the storage requirements of dornase Alfa?

Refrigerate and protect for light

16

What are the common side effects are of dornase Alfa?

Voice alternations
Inflammation of larynx and pharynx
Rash
Chest pain

17

What are some expectorants?

MSGS
SSKI(iodine containing)
Sodium bi-carb
Guaifenesin
Mannitol(oligosaccaride)

18

What is something you give a patient before using broncotol?

SABA

19

What do beta agonists do to cilia?

-Increase beat frequency, but doesn't really effect mucous clearance

20

What's an issue with using a bronchodilator for airway clearance?

It opens up the airway, but by relaxing the airway, it can cause collapse in floppy airways.
This can cause plugging

21

What are some mucokenetic agents?

Bronchodilators
Surface phospholipids

22

What is the % concentration of hypertonic saline?

7%

23

Which patients are too risky to give gravity postural drainage therapies to?

GERD
Muscle weakness

24

What is insufflation/exsufflation exercise?

Using machines to give positive pressure to inflate then negative pressure to stimulate coughing

25

Who would benefit from insufflation/exsufflation exercises?

-COPD
-neurological muscle weakness patients who can't cough

26

What are the steps of the active cycle breathing (ACB)?

-take breath at mid-volume inhale
-squeeze are out air from chest and abdomen
(It shouldn't be a violent huff)

27

What is a mucolytic agent?

An agent that breaks down mucus

28

What is a cause for decreased secretions in CF patients?

Defective ion transports for sodium and chloride

29

What 2 destructive forces do bronchial secretions stop?

-alpha 1 protease enzymes
-leukoproteases

30

What are some diseases involved in hypersecretion is mucus?

-chronic bronchitis
-asthma
-bronchorrhhea