Flashcards in Chapter 9 - Mucus Drugs Deck (39)
What are the surface epithelial cells of the mucociliary system?
Pseudo stratified columnar Ciliated
What are the cells in the submucosal layer?
What sputum composed of?
Mixed inflammatory cells
What drugs are called mucoregulatory medications?
What are mucoregulatory drugs useful in?
Broncorrhea associated with airway inflammation.
What are some therapeutic options for hypersecretion?
Remove causative factors
Use mucoactive agents when indicated
What is mucomyst used for?
What is the mode of action for mucomyst?
Disrupts Di-sulfide bonds
What's a hazard of mucomyst?
What are some secondary complications of mucomyst?
What are you not allowed to mix with NAC?
What is dornase Alfa used for?
-Mucoactive agent for CF pts and to preserve or improve their LUNG FUNCTION
-to reduce respiratory infections that require paraenteral antibiotics
What does dornase Alfa do to non-CF airways diseases?
What is the mode of action of Dornase alfa?
Decreases viscocity and adhesivity
-decreases DNA of sputum
What are the storage requirements of dornase Alfa?
Refrigerate and protect for light
What are the common side effects are of dornase Alfa?
Inflammation of larynx and pharynx
What are some expectorants?
What is something you give a patient before using broncotol?
What do beta agonists do to cilia?
-Increase beat frequency, but doesn't really effect mucous clearance
What's an issue with using a bronchodilator for airway clearance?
It opens up the airway, but by relaxing the airway, it can cause collapse in floppy airways.
This can cause plugging
What are some mucokenetic agents?
What is the % concentration of hypertonic saline?
Which patients are too risky to give gravity postural drainage therapies to?
What is insufflation/exsufflation exercise?
Using machines to give positive pressure to inflate then negative pressure to stimulate coughing
Who would benefit from insufflation/exsufflation exercises?
-neurological muscle weakness patients who can't cough
What are the steps of the active cycle breathing (ACB)?
-take breath at mid-volume inhale
-squeeze are out air from chest and abdomen
(It shouldn't be a violent huff)
What is a mucolytic agent?
An agent that breaks down mucus
What is a cause for decreased secretions in CF patients?
Defective ion transports for sodium and chloride
What 2 destructive forces do bronchial secretions stop?
-alpha 1 protease enzymes