Chapter 18 Flashcards

(46 cards)

1
Q

common; causes vaginal discharge,

itching, and irritation due to yeast infection.

A

vaginitis

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2
Q

an inflammation of the fallopian tubes,
along with ovaries at times; due to the cause of
secondary to the spread of cervical _____ or
______ infection. PID predisposes to ____
pregnancy (implantation of the ovum in the fallopian
tube)

A
Salpingitis / PID (also called pelvic inflammatory
disease)
gonorrheal
chlamydial
ectopic
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3
Q
Outside uterine cavity
– 95% Fallopian tubes
• \_\_ in every 200 pregnancies
• Most are symptomatic
• Predisposing factors
– \_\_\_\_ infections
– Previous \_\_\_\_
– \_\_\_ use
– previous ectopic pregnancy
history
-missed \_\_\_\_\_
-other signs of \_\_\_ pregnancy
-\_\_\_\_ bleeding 6-8 weeks after last period 
-upon rupture, bleeding may be excessive 
-lower abdominal pain
may be sharp unilateral
constant
diffused or localized 
may be referred to \_\_\_\_\_\_
A
ectopic pregnancy
1
tubual
PID
IUD
period
vaginal 
shoulder
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4
Q

________ or unexplained ________ + woman of __________ age = ectopic pregnancy
until proven otherwise!

A

abdominal pain
hypovolemia
child bearing

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5
Q

known as super estrogen
Nonsteroidal estrogens used from 1946–1970 to
treat mothers who were prone to spontaneous
______
• Disorders in ______ of women who received
diethylstilbestrol (DES) therapy during pregnancy.
• _________: Puberty before the specified
age
• ______ adenocarcinoma of the cervix and vaginal
adenosis (benign condition characterized by
mucosal ______ epithelium-lined changes) in
areas normally lined by _______
epithelium (metaplasia), may also occur in these
patients.

A
diethylstilbestrol (DES)
abortion
daughters
precocious puberty
clear cell
columnar
stratified squamous
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6
Q

Deep penetration of the placental
villi into the wall of uterus. Patients with previous
cesarean section are pre disposed to this condition.
Treatment: surgery to stop ______

A

placenta accreta

bleeding

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7
Q

implantation of the zygote in the lower section of the uterus– Patients experience
painless bleeding. Treatment is delivery by ______

A

placenta previa

C-section

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8
Q

Partial/complete premature
separation of the placenta which is an obstetric
emergency for mother and fetus- Patients experience
painful bleeding with abdominal pain. Treatment:
immediate_____ & control ______

A

abruptio placentae

delivery, bleeding

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9
Q

Termination of pregnancy before the 22 th week of gestation.
• Signs and symptoms include cramping, abdominal pain,
backache, and vaginal bleeding.

A

abortion

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10
Q

• _____ or ________competes with progesterone
for the progesterone receptors.
• Mechanism of action: Without progesterone, the
lining of the women’s uterus breaks down and sheds
like normal menstrual cycle. In addition, the drug opens
the ____ and influence contractions with help of
_____ to dislodge and expel the embryo. Ru-
486 works only during the first __ weeks of pregnancy,
or up to 63 days from the start of the women’s last
menstrual period. After this time, the level of
progesterone goes up in a higher level where RU-486
is not effective.

A
progesterone antagonist
RU-486, Mifepristone
cervix
prostaglandin
9
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11
Q
False labor that increases in intensity and
frequency but does not cause cervical
change
• Most of the time \_\_\_\_ condition.
• Sometimes \_\_\_\_\_ test on the vaginal
fluid for pre-term labor
A

Braxton-Hicks Contractions
benign
fibronectin

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12
Q

Gestational Trophoblastic Disease
______mole (placental abnormality): swelling of the
chorionic villi. Uterus expands as if a normal pregnancy is
present, but the uterus is much larger.
•______much higher than expected for date of gestation.
Classically presents in the _____ trimester as passage of
_____-like masses through the vaginal canal. Moles are
diagnosed by routine _____ in the early first trimester.
Fetal ______ are absent, and a ‘_______’ appearance
is classically seen on ultrasound. Two types:
_______: Fetus can not be identified in the ammnotic
fluid due to due to production of _____. No ______
chromosome only ______ chromosome.
_______: Some the fetal parts are present. Thought
to be due to fertilization of the ovum by two or more
________
treatment: Most moles abort spontaneously or D&C
(_____ &______. Chemical Pregnancy
• ___________: malignant tumors of
germ cells of the placenta: Rare. But, 50% develops
from ______ mole, 25% develops from
placental cells after _____and 25%, develops from
_____ placenta.
Clinical findings: High levels of ____
Treatment: ______

A
Hydatidiform
B-hCG
second
grapelike
ultrasound
heart sounds
snowstorm
complete mole
androgen
maternal, paternal
incomplete mole
spermatozoa
dilatiation
gestational choriocarcinoma
hydatidiform
abortion
normal
hCG
chemo
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13
Q

toxemia of pregnancy
This disorder is characterized by severe _____
that most often occurs ______during pregnancy or
complicates preexisting hypertensive disease.
Toxemia characteristically occurs during the ____
trimester, most often in the ____ pregnancy,
• Preeclampsia: triad of ______, _____ and
_______ during the 3rd trimester. HELLP syndrome,
there may be _____, _______ and _______
• Eclampsia: all of the above plus _____
Treatment:
Preeclampsia: Delivery of the fetus, ______, treat
______
Eclampsia: Medical ______, treat with ________ and ______ (anti-epileptics)

A
hypertension
de novo
preexisting
3rd
first
hypertension, edema, proteinura
hemolysis, elevated liver enzymes, low platelets
seizures
bed rest
hypertension
emergency
magnesium
diazepam
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14
Q

Uterus compresses inferior vena cava
 Venous return to ____ decreases
 Decreased venous return leads to decreased
________
 ____ decreases.
 Management
• Place patient on __ side to restore venous
return
• All non-laboring patients in late pregnancy
should be on ___ side

A
supine hypotensive syndrome
heart 
cardiac output
BP
left
left
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15
Q

prologed (>7 days) and or heavy (>80 mL) uterine bleeding at regular intervals

A

menorrhagia

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16
Q

variable amounts of inter menstrual bleeding occuring at irregular but frequent intervals

A

metrorrhagia

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17
Q

an abnormally short interval (<21 days) between regular menses

A

polymenorrhea

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18
Q

an abnormally long interval (>35 days) between regular menses

A

oligomenorrhea

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19
Q

the medical term for pain with menstruation

20
Q

is common menstrual cramps
that are recurrent and are not due to other diseases.
Cramps usually begin __ to __ days after a woman
starts getting her period. Pain usually begins 1 or 2 days
before or when menstrual bleeding starts and is felt in the
lower_____ ____ , or ___ and can range from mild
to severe. Pain can typically last 12 to 72 hours and can
be accompanied by nausea, vomiting, fatigue, and even
diarrhea. Common menstrual cramps usually become
less painful as a woman ages and may stop entirely if the
woman has a baby.

A

primary menorrhea
1, 2
abdomen, back, thighs

21
Q

is pain that is caused by a
disorder in the woman’s reproductive organs, such as
_____, _______, or ____. Pain from
secondary dysmenorrhea usually begins earlier in the
menstrual cycle and lasts _____ han common
menstrual cramps. The pain is not typically
accompanied by nausea, vomiting, fatigue, or
diarrhea. Treatment: ____, Other anti-inflammatory
drugs and Oral contraceptive pills.

A
secondary dysmenorrhea
endometriosis, uterine fibroids
infection
longer
aspirin
22
Q

Failure to have a period
during puberty. Patients usually have birth defects
like ______ or other ______ defects

A

primary amenorrhea
Turner syndrome
congenital

23
Q

when a woman has
normal menstrual cycles but stopped having her
period for 6 months or longer. Exception- women
who are pregnant, breastfeeding or in menopause.
Common factors contributing are: drugs
(________ ), _______ , ___ body weight,
______ problems

A
secondary amenorrhea
6
chemo, anti deppresents 
low
hormonal
24
Q

menstrual cycle stops
in young female (non-pregnant) without any
evidence of abnormalities with pituitary or ovaries.
Common with ______ or usage of ______

A

psychogenic amenorrhea
college freshman
opiates

25
amenorrhea: secondary b) _______ Amenorrhea:- increased of PRL due to nursing a baby • c) Anorexia Nervosa:- decreased body weight: decreased ___ and ___: decreased _____ production. • d) Exercise Amenorrhea:- delayed ______, _____ dysfunction and amenorrhea are known as female ______ (decreased FSH & LH) • e) _____ Amenorrhea:- long distance female runners produce ______ which inhibit_____ production. Treatment: ___, decrease ____ and _____ pills.
``` lactational anorexia nervosa FSH, LH estrogen menarche luteal phase athletic triad Runner's Beta endorphins GnRH diet, excersize, birth control ```
26
• Pubertal delay in girls due to low estrogen • An absent or structurally abnormal second chromosome characterizes Turner Syndrome (45 or 46 XO chromosomes). • In absence of second functional X chromosome, oocyte degeneration happens because of primary _____ failure, which causes ____ and ___ rise and are elevated at birth and again at puberty. • Symptoms: 10 – 20% Turner girls, some ovarian functions at puberty that allow for slight ____ development, ___ stature, _____ neck, abnormal upper to lower ____ ratio, primary ____. • Treatment _____ and ______ and height with _____ hormone
``` other female disorders: turner syndrome gonodal FSH, LH breast, short, webbed, segment, amennorhea estrogen, progesterone growth ```
27
Deposits of endometrium outside its normal location, Most often located on the ovary and pelvic peritoneum • Causes may include ______ flow of endometrial fragments through fallopian tubes during menstruation, with implantation on the ovary or other peritoneal structures. • The condition is characteristically responsive to _____ variations of the menstrual cycle. ______ bleeding occurs into the _____ endometrium, resulting in blood-filled, or so-called “_______” cysts. Endometriosis occurs most often in the ____ area; the ____ is the most common site, followed by the ____ ligaments and pelvic area. • Clinical manifestations include severe menstrualrelated pain (______). Endometriosis is ______ and has no relation to endometrial cancer. It often results in _____ • Diagnosis: visualizing the ectopic deposits within the pelvis with a ______ • Treatment: Birth control pills, and drugs that suppress output of gonadotropins from the pituitary gland.
``` endometriosis retrograde hormonal menstrual type ectopic chocolate pelvic ovaray uterine dysmenorrhea nonneoplastic infertility laparascope ```
28
``` Inflammation of the endometrium or uterine lining by bacterial infection. • May be caused by ___ or ____ • Symptoms include _____, fever, constipation, vaginal bleeding, and pelvic pain. • Treatment: ```
endometritis STD, surgery malaise antibiotics
29
Sexually transmitted DNA virus that infects the lower genital tract, especially the cervix • Infection is usually eradicated by acute inflammation & persistent infection leads to an increased risk for cervical dysplasia (____________) . • Risk of CIN depends on HPV type (determined by __sequence). • High-risk—HPV types 16, 18, 31, and 33 • Low-risk—HPV types 6 and 11 • High-risk HPV produce ___ and __ proteins which result in increased destruction of ___ and __ (tumor suppressor proteins) which increases the risk for CIN.
``` HPV cervical intraepithelial neoplasia (CIN DNA E6, E7 p53, Rb ```
30
Most physicians regard cervical dysplasia and in situ carcinoma as very closely related, constituting different stages in a progressive spectrum of epithelial abnormalities, classifying them under the general term, cervical intra-epithelial neoplasia (CIN). Disordered epithelial growth manifested by loss of polarity and nuclear hyperchromasia, beginning at the basal layer and extending outward, is characteristic. It is graded into three categories: • Grade I: CIN 1Mild dysplasia • Grade II: Moderate dysplasia • Grade III: Severe dysplasia (carcinoma in situ)
Cervical Intraepithelial Neoplasia (CIN)
31
Most physicians regard cervical dysplasia and in situ carcinoma as very closely related, constituting different stages in a progressive spectrum of epithelial abnormalities, classifying them under the general term, ____________ Disordered epithelial growth manifested by loss of____ and nuclear ______, beginning at the basal layer and extending outward, is characteristic. It is graded into three categories: • Grade I: CIN 1 ____ dysplasia • Grade II: ____ dysplasia • Grade III: _____ dysplasia (carcinoma ____ )
``` Cervical Intraepithelial Neoplasia (CIN) polarity, hyperchromasia Mild Moderate Severe in situ ```
32
Diagnosis and Treatment of Dysplasia and Carcinoma • The goal of screening is to catch dysplasia (___) before it develops into carcinoma. • Progression from CIN to carcinoma, on average, takes __-__ years. Screening begins at age __ and is initially performed yearly. • _____ is the gold standard for screening. • Cells are scraped from the transformation zone using a brush and analyzed under a microscope. • _____ cells are classified as low grade (CIN I) or high grade (CIN II and III). High-grade dysplasia is characterized by cells with _______ (dark) nuclei and high ____ to _____ ratios. • Pap smear is the most successful screening test • Hybrid Capture 2 Technology: new test based on RTPCR • Treatment: Dysplasia and in situ carcinoma: _____ (freezing) _______ of abnormal area, ______ (removal of uterus). • Invasive carcinoma: radiation or radical hysterectomy (resection of uterus, fallopian tubes, ovaries, and adjacent tissues)
``` CIN 10-20 years 21 pap smear dysplastic hyperchromatic nuclear, cytoplasmic cryocautery surgical excision hysterectomy ```
33
tumors of the uterus This is the most common uterine tumor and the most common of all tumors in women; the incidence is increased in women of ____ lineage. The tumor is a benign neoplasm; malignant transformation is rare. - occur in multiple ____ foci in most cases. The tumors are ____-sensitive. They often increase in size during _____, and they almost always decrease in ________
``` Leiomyoma African separate estrogen pregnancy menopause ```
34
tumors of uterus | malignant, rare
leiomyosarcoma
35
Adenocarcinoma. Occurs in perimenopausal and postmenopausal (older) women
endometrial tumors
36
Malignant neoplasm (abnormal growth) located on the ovaries. • 5th Leading cause of cancer death in ♀ and leading cause of death from gynecological malignancies. • -_____ ♀ @ higher risk (post-menopasual). • prognosis is _____ . Symptoms are vague and non-specific conditions. • Symptoms: - ____ heaviness, ______ discomfort, _____ bleeding, Weight gain or loss, _____menstrual cycles • Thus, 50% of ♀ with ovarian cancers are diagnosed in the advanced stages of the disease • Factors protecting ♀ from ovarian cancer: ____ pregnancy, Use of _______ • Risk Factors: Presence of ___ and ____ (mutated) genes increase breast and ovarian cancers Higher ____ fat content, _____ • Testing: Blood chemistry, ____, ultrasound, CT, MRI, pelvic exam, and PAP smear (♀ over ___ yrs old) If diagnosed in early stages, survival rate is higher. • Treatment: ____ (yew tree derivative) Regression of ovarian cancer by disrupting the cellular structures of tumor. _______.
``` ovarian cancer older poor heaviness, abdominal vaginal, abnormal early age oral contraceptives BRCAI, BRCAII dietary smoking CA 125 20 Taxol anti-estrogens ```
37
ovarian tumors: epithelium cystadenoma 1. Serous – tumor epithelium resembles epithelium lining _____ tube 2. Mucinous – tumor epithelium resembles mucussecreting epithelium of ______
fallopian | endocervix
38
Serous and Mucinous Endometrial – tumor epithelium resemble endometrium. Most ovarian tumors with endometriumlike epithelium are malignant
cystadenocarcinoma
39
• Occur in women younger than 25 years old • Common germ cell tumor: ___(Mature: benign) • Contain ____ or ____ parts • Mature teratoma presents a ___ structure and teeth: it is known as _____ cyst • Malignant tumors (immature teratoma: rapidly metastasize) may secrete ___ and ___
``` ovarian tumors: germ cells teeth, calcified hairy dermoid AFP, hCG ```
40
Hormonally inactive and may produce estrogen which cause mentrual irregularities.
granulosa cell tumor
41
are solid tumors and produce estrogen. They are benign in nature and often cause endometrial hyperplasia.
Theca cell tumor
42
are solid tumors and produce androgens which cause masculine characteristics.
Sertoli-Leydig cell tumor
43
Metastases to the Ovaries due to secondary causes • Tumors metastatic to the ovary account for approximately 5% of all ovarian tumors. • These tumors are frequently of gastrointestinal tract, breast, or endometrial origin. • They are called _____ tumors when ovaries are replaced bilaterally by ___ secreting signet ring cells and the site of origin is often the _____
Krukenberg mucin stomach
44
• Involves enlarged ovaries, which contain many fluid-filled sacs (cysts), and a tendency to have high levels of male hormones (androgens). Not all women with PCOS have cysts. • A main underlying problem with PCOS is a hormonal _____. In women with PCOS, the ovaries make more androgens than normal. High levels of these hormones affect the development and release of eggs during ovulation. • Researchers also think ____ may be linked to PCOS. Many women with PCOS have too much insulin in their bodies because they have problems using it. Excess insulin appears to increase production of androgen. High androgen levels can lead to: ___, _____, weight gain and ____ problems. • Blood tests to measure levels of LH and male hormones are performed, and ultrasonography of the ovaries may be performed. No ideal treatment is available. The choice of treatment depends on the type and severity of symptoms, the woman's age, and her plans regarding pregnancy. • Women who do not wish to become pregnant may take ______ by mouth or a combination oral contraceptive (which contains estrogen and a progestin). • The medicine _____ (Glucophage) is used to treat type 2 diabetes. It also has been used in PCOS, but not approved by FDA for this use. Metformin affects the way insulin controls blood glucose (sugar) and lowers _______ production. It slows the growth of abnormal hair and, after a few months of use, may help ovulation to return. Recent research has shown metformin to have other positive effects, such as decreased body mass and improved cholesterol levels. Metformin will not cause a person to become diabetic.
``` Polycystic ovary syndrome (PCOS) imbalance insulin acne, hirutism, gain, ovulation progestin metformin testosterone ```
45
– Irregular white patches on vulvar skin – May progress to carcinoma due to HPV or non HPV related
vulvular dystrophy
46
• Estimated 10-15 cases per 100,000 menstrual age women per year • This condition was initially associated with the use of highly absorbent tampons. It is caused by _____ produced by ____, which grows in the tampon. • Use of tampons promotes development • Characteristic features include fever, vomiting, and diarrhea, sometimes followed by renal failure and shock. A generalized rash often seen in patients
toxic shock syndrome exotoxin S. aureus