Chapter 27 Flashcards
(26 cards)
Extracellular
- in body cavity
- interstitial fluid
- plasma
Intercellular
Within cells
Interstitial fluid
Surrounding cells
Plasma
Component of blood
Fluid dynamics
Movement of fluid between divisions ( intercellular ~ interstitial ~ plasma)
^ ^
Osmosis Capillary exchange
Pre-formed water
Ingested water
Metabolic water
Water created as by-product of metabolism (electron transport)
Electrolytes
- dissolved minerals
* types: anions cations
Anions
Negatively charged electrolytes
Cations
Positively charged electrolytes
Function of electrolytes
Control osmosis and regulate pH
Water
- Maintain water balance
- water loss via urination, defamation, perspiration, and respiration
- generates dehydration
Electrolyte components
• via. Hormonal secretion
Electrolytes in kidneys
• regulate amount lost in urine
Ex: aldosterone -causes increased levels of Na+, Cl-, and Mg+2 in body fluids and decreased levels of K+
Electrolytes in tissues
•Regulate storage/release of electrolytes from body tissues
Ex: calcitonin - storage of Ca+2 and PO4-2
* parathyroid hormone other - release of Ca+2 and PO4-2 from bones and teeth
pH
- measures on scale 0-14
- based on relative amount of H+ and OH - present
- pH < 7 acidic fluid (decreased pH = increased H+)
- pH > 7 basic fluid (increased pH = decreased H+)
- pH = 7 neutral fluid
Buffer system
Converts strong acids and bases to weak ones (HCL ~ H+,CL)
Protein buffer
- pH down (excess H+ picked up by amine (NH2h group
* pH up (carboxyl group (COOH) release H+)
Hemoglobin/oxyhemoglobin buffer
•Hb=hemoglobin •HbO2=oxyhemoglobin •CO2 in blood firms carbonic acid (H2CO3) *release H+ (H2CO3 ~ HCO3 + H+) • oxyhemoglobin (HbO2) releases O2 * becomes negatively charged (Hb-) * binds with free H+ (HbH)
Respiration
•regulate amount of Carbonic in blood
• decreased pH lead to:
*increased respiration rate
* eliminates CO2 and thus carbonic acid from blood
• increase pH leads to:
* decreased respiration rate
* allows build up of CO2 and thus carbonic acid in blood
Tubular secretion
•kidneys
• decreased pH leads to:
* increased tubular secretion of H+ into urine
* less H+ in blood raises pH
• increased pH leads to:
* decreased tubular secretion of H+ into urine
* more H+ in blood lowers pH
Acidosis
- sustained decrease in pH
* depresses activity of nervous system
Causes of acidosis
- respiratory - due to hypoventilation
* metabolic due to sustained increase in metabolic rate and kidney failure
Alkalosis
- sustained increase in pH
* hyper-stimulation of the nervous system