chapter six

Question 1

what was the first NT discovered

Answer 1

acetylcholine

Question 2

criteria to be an NT: 3 things

Answer 2

synthesized and stored in presynaptic terminal
released by presynaptic axon terminal
produces response in postsynaptic cell

Question 3

uses antibodies to show where proteins are
can label peptide NT’s or synthetic enzymes (not amino acids)

Answer 3

immunocytochemistry

Question 4

shows what neurons are producing specific mRNA transcripts
probe binds to a specific strand of mRNA in the neuron

Answer 4

in situ hybridization

Question 5

sample molecules within the extracellular space, can be done in awake, behaving animals

Answer 5

microdialysis

Question 6

every NT receptor binds to ___ ____ NT

Answer 6

only one

Question 7

uses radioactive ligand to label receptors

Answer 7

quantitative autoradiobiography

Question 8

one neuron, one NT

Answer 8

dale’s principle

Question 9

amino acid NT

Answer 9

glutamate, GABA

Question 10

amines NT

Answer 10

acetylcholine, dopamine, serotonin

Question 11

used to package the neurotransmitter into vesicles

Answer 11

transporters

Question 12

necessary to make the transmitter from precursor- neurons don’t produce enzymes to make transmitters they don’t use

Answer 12

synthetic enzyme

Question 13

thing that controls how fast the synthesis of a neurotransmitter happens

Answer 13

rate-limiting enzyme

Question 14

two receptors that mediate most of the fast excitatory transmissions in the brain

Answer 14

AMPA and NMDA

Question 15

voltage dependent NMD channels are _____ ______; they need both glutamate binding and membrane depolarization for channel to become permeable

Answer 15

coincidence detectors

Question 16

____ mediates inhibitory transmission

Answer 16

GABA

Question 17

the ______ of their binding sites describes which NTs affect them and how drugs interact with them

Answer 17

pharmacology

Question 18

the _____ of the NT binding process and channel gating determine the duration of their effect

Answer 18

kinetics

Question 19

the _______ of the ion channels determines whether they produce excitation or inhibition

Answer 19

selectivity

Question 20

the _____ of open channels helps determine the magnitude of their effects

Answer 20

conductance

Question 21

one NT, multiple receptor subtypes; greater postsynaptic response

Answer 21

divergence

Question 22

Different NTs affect same effector system (exception to rule)

Answer 22

convergence