Chemo Drugs Reduced 2 Flashcards Preview

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Flashcards in Chemo Drugs Reduced 2 Deck (13):
1

Alkylating Agents

Bind covalently to DNA
cell cycle non specific
DNA drug intrastrand and interstrand crosslink
Alkylate N-7 guanine

2

Resistance to Alkylating agents

enhanced DNA repair or binding to sulfur containing molecules

3

cyclophosphamide and ifosfamide

mensa for hematuria(active in urine)
myelosuppression dose limiting

4

Temozolomide

monofunctional alkylating agent
Prophylaxis PCP pneumonia with long term use
TREAT: Primary brain tumor (glioblastoma with radiation treatment)

5

Pt Coordination Compounds

Non classical DNA alkylating agent
Pt 2+ oxidation state
leaving group cis
N7 of adenine and guanine
Aquation to DNA reactive species
-can be bound by sulfur and not make it

6

Cisplatin

Nephrotoxic and Ototoxic
Chloruresis helps protect kidney (can't do if heart failure can't handle)
TREaT: Testicular cancer (CURATIVE)

7

Carboplatin

Not nephrotoxic
Myelosuppression dose limiting

LInear relationship between GFR and plasma clearance
-AUC calculation:
dose=AUC X (GFR +25)

Cross resistant with cisplatin

8

Oxaliplatin

Myelosuppression dose limiting
vein irritant
Acute induced neuropathy
chronic sensory neuropathy

TREAT: Metastatic colorectal cancer (doubling survival rate)

9

Vincristine, Vinblastine

periwinkle plant

M phase specific
prevents polymerization of tubulin

Excretion via bile
-patients with elevated bilirubin require dose reduction

Vincristine:
Neuropathy dose limiting
No myelosuppression

(christ my nerves)
(blast my bones)



10

Paclitaxel

M phase
Prevent tubulin disassembly
Hepatic metabolism

Myelosuprresion and Neuropathy
Premedication to prevent allergic reactions
Dose reduction needed in hepatic dysfunction

Used in: ovarian and breast lung, gastroesophageal

11

Docetaxel and Cabazitaxel

prostate

12

Albumin bound paclitaxel

-albumin bound paclitaxel (no allergic reactions, less myelosuppression and neuropathy)

13

Etoposide

G1-S phase
Topoisomerase 2 target
Produces DNA double strand breaks
Myelosuppression dose limiting
Dose reduction for renal/hepatic dysfunction

Testicular, lung, lymphoma