Flashcards in 5 Individualizing Therapy Deck (10)
What are the 4 main pharmacological principles?
how the drug gets into the body from the site of administration
WIll the medication reach its target
-area of the body
What are physiological barriers to to the drug reaching its target area?
-decreased protein-->potential increased Vd
-increased protein-->challenged Vd
What are difficult areas to penetrate?
BBB, bone, eye
Reported calcium levels measure calcium bound to albumin, so what can low albumin lead to?
falsely low calcium levels
-80% of calcium bound to albumin
corrected calcium for low albumin
=measured calcium + .8(4-albumin)
What is metabolism?
How a medication is broken down to less active more soluble by-products
Why is a loading dose given?
To achieve an immediate therapeutic response
-levels approximate those seen at steady state
-steady state NOT reached any faster sill 3-5 half lives need
When are dose adjustments best made?
-when the patient is at steady state