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Flashcards in 5 Individualizing Therapy Deck (10):
1

What are the 4 main pharmacological principles?

1. absorption
2. distribution
3. metabolism
4. elimination

2

Absorption

how the drug gets into the body from the site of administration

3

Distribution

WIll the medication reach its target
-area of the body
-perfusion

4

What are physiological barriers to to the drug reaching its target area?

-protein binding
-decreased protein-->potential increased Vd
-increased protein-->challenged Vd

5

What are difficult areas to penetrate?

BBB, bone, eye

6

Reported calcium levels measure calcium bound to albumin, so what can low albumin lead to?

falsely low calcium levels
-80% of calcium bound to albumin
corrected calcium for low albumin
=measured calcium + .8(4-albumin)

7

What is metabolism?

How a medication is broken down to less active more soluble by-products

8

Why is a loading dose given?

To achieve an immediate therapeutic response
-levels approximate those seen at steady state
-steady state NOT reached any faster sill 3-5 half lives need

9

When are dose adjustments best made?

-when the patient is at steady state

10

What is steady state dependent on?

half life