General Anesthetics Flashcards Preview

Pharm > General Anesthetics > Flashcards

Flashcards in General Anesthetics Deck (10):
1

Higher lipid solubility

higher potency

2

What is potency influenced by?

temp, age, rx

not sex, o2, ph, bp

3

How does cardiac output affect inhalation anesthetics?

-increased cardiac output-->slower induction

4

What is FA/FI?

End tidal/Inspired
Fa=is the brain partial pressue

5

how do you increase speed of induction

increase delivery

6

What are the three main factors that determine uptake into blood?

1. solubility
-not soluble reaches equilibrium faster and blood compartment is smaller
2. partial pressure difference
-partial pressure drives movement not concentration
3. cardiac output
-decreased cardiac output faster

7

Propofol

-sedation
-IPSP-GABA?
-decreased CMRO2 and ICP
-dilator
-respiratory depression

8

Ketamine

-dissociative anesthesia-short procedures
*NMDA receptor antagonist
-increased CMRO2 and ICP
**increased BP and heart rate
**bronchodilator-keep breathing
-bad dreams, salivation, twitchy

9

Ketamine

-dissociative anesthesia-short procedures
-NMDA receptor antagonist
-increased CMRO2 and ICP
**increased BP and heart rate
**bronchodilator-keep breathing
-bad dreams, salivation, twitchy

10

etomidate

-GABA
-decreased CRO2
-constrictor
**least cardiovascular side effects
**adrenal supression