Chlamydia, Rickettsia, Ehrilichia, Mycoplasma Flashcards Preview

Micro Final > Chlamydia, Rickettsia, Ehrilichia, Mycoplasma > Flashcards

Flashcards in Chlamydia, Rickettsia, Ehrilichia, Mycoplasma Deck (68)
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1

What distinguishes Chlamydiae from other microorganisms?

VERY small bug (similar in size to some viruses) and it has NO peptidoglycan

2

Where does Chlamydiae grow?

Obligate intracellular pathogens (must grow inside other cells)

3

Why is Chlamydiae an obligate intracellular pathogen?

It depends on the host for ATP

4

What are the two classifications of Chlamydia and how do they differ?

1. Chlamydia - Humans only
2. Chlamydophila - Mainly humans but also infect animals

5

What is the most common agent of sexually transmitted bacterial infections?

Chlamydia trachomatis

6

What is something that Chlamydia trachomatis can lead to?

Blindness

7

How is Chlamydia trachomatis spread?

Droplet of direct contact

8

Delayed-type hypersensitivity in Chlamydia trachomatis can be caused by what substance?

Chlamydial heat shock protein

9

Which type of Chlamydia can survive outside of a host cell?

Elementary bodies (extracellular) (spore-like)

10

Which type of Chlamydia is found within host cells?

Reticulate bodies (vegetative-like)

11

How is Chlamydia internalized by the body?

Receptor-mediated endocytosis

12

What disease does Chlamyda trachomitis cause?

Trachoma

13

What is lymphogranuloma venerum?

Systemic infection in lymph nodes that drain the genital tract (reaction to Chlamydial heat shock protein!)

14

What is the most prevalent chlamydial pathogen in the human population?

Chlamydophila pneumoniae

15

What is Chlamydophila psittaci?

Chlamydiophila found in birds which can be transferred to humans by inhalation of avian fecal dusts causing flu-like illness

16

Why is it difficult to treat Chlamydiae?

Must penetrate FOUR MEMBRANE LAYERS.(Host plasma membrane, inclusion membrane, chlamydial outer membrane, chlamydial cytoplasmic membrane)

17

What disease does Rickettsiae rickettsii cause?

Rocky Mountain Spotted Fever

18

What disease does Rickettsiae prowazekii, R. typhi, and R. tsutsugamushi cause?

Typhus

19

How does Rickettsiae insert into host cells?

They attach to vascular endothelial cells (small blood vessels) and induce endocytosis.

20

How does Rickettsiae exit the host cell?

Each strain has a different mode for exit

21

What is something defining about Coxiellaburnetti?

Extremely stable with spore-like structure (But not spores)

22

What is the mode of infection of Coxiella burnetti?

Inhalation of airborne particles (NO ARTHROPOD VECTOR NECCESSARY)

23

Once in the body, what is Coxiella burnettis mode of entry/spread?

Tharget macrophages and multiply in phagolysosome

24

What is Acute Q (Query) fever

Asymptomatic - may feel ill for a few days or weeks.

25

What is Chronic Q (Query) fever?

Results in endocarditis and can be fatal

26

What types of cells does Ehrlichia target?

Monocytes and macrophages

27

How does Ehrlichia multiply/spread?

Similar system to Chlamydiae but involves Dense-core cells (elementary bodies) and reticulate cells (Reticulate bodies)

28

What is special about Mycoplasma?

1. Smallest organisms capable of growth on cell-free media.
2.Requires sterol (cholesterol) to be added because it HAS NO CELL WALL (no murein) so it's not sensitive to penicillin

29

What is hemolytic anemia?

With Mycoplasma infection, IgM is secreted and at lower temperatures, when mixed with RBC, cause RBC to stick together. Happens in 50% of cases of infection.

30

Describe the unique physical properties of Chlamydiae

•Small (.25 µm - .8 µm)
•Just at limit of light microscopy
•Similar in size to some viruses
•Gram negative
•No peptidoglycan (murein) in cell walls