Flashcards in Chlamydia, Rickettsia, Ehrilichia, Mycoplasma Deck (68)
What distinguishes Chlamydiae from other microorganisms?
VERY small bug (similar in size to some viruses) and it has NO peptidoglycan
Where does Chlamydiae grow?
Obligate intracellular pathogens (must grow inside other cells)
Why is Chlamydiae an obligate intracellular pathogen?
It depends on the host for ATP
What are the two classifications of Chlamydia and how do they differ?
1. Chlamydia - Humans only
2. Chlamydophila - Mainly humans but also infect animals
What is the most common agent of sexually transmitted bacterial infections?
What is something that Chlamydia trachomatis can lead to?
How is Chlamydia trachomatis spread?
Droplet of direct contact
Delayed-type hypersensitivity in Chlamydia trachomatis can be caused by what substance?
Chlamydial heat shock protein
Which type of Chlamydia can survive outside of a host cell?
Elementary bodies (extracellular) (spore-like)
Which type of Chlamydia is found within host cells?
Reticulate bodies (vegetative-like)
How is Chlamydia internalized by the body?
What disease does Chlamyda trachomitis cause?
What is lymphogranuloma venerum?
Systemic infection in lymph nodes that drain the genital tract (reaction to Chlamydial heat shock protein!)
What is the most prevalent chlamydial pathogen in the human population?
What is Chlamydophila psittaci?
Chlamydiophila found in birds which can be transferred to humans by inhalation of avian fecal dusts causing flu-like illness
Why is it difficult to treat Chlamydiae?
Must penetrate FOUR MEMBRANE LAYERS.(Host plasma membrane, inclusion membrane, chlamydial outer membrane, chlamydial cytoplasmic membrane)
What disease does Rickettsiae rickettsii cause?
Rocky Mountain Spotted Fever
What disease does Rickettsiae prowazekii, R. typhi, and R. tsutsugamushi cause?
How does Rickettsiae insert into host cells?
They attach to vascular endothelial cells (small blood vessels) and induce endocytosis.
How does Rickettsiae exit the host cell?
Each strain has a different mode for exit
What is something defining about Coxiellaburnetti?
Extremely stable with spore-like structure (But not spores)
What is the mode of infection of Coxiella burnetti?
Inhalation of airborne particles (NO ARTHROPOD VECTOR NECCESSARY)
Once in the body, what is Coxiella burnettis mode of entry/spread?
Tharget macrophages and multiply in phagolysosome
What is Acute Q (Query) fever
Asymptomatic - may feel ill for a few days or weeks.
What is Chronic Q (Query) fever?
Results in endocarditis and can be fatal
What types of cells does Ehrlichia target?
Monocytes and macrophages
How does Ehrlichia multiply/spread?
Similar system to Chlamydiae but involves Dense-core cells (elementary bodies) and reticulate cells (Reticulate bodies)
What is special about Mycoplasma?
1. Smallest organisms capable of growth on cell-free media.
2.Requires sterol (cholesterol) to be added because it HAS NO CELL WALL (no murein) so it's not sensitive to penicillin
What is hemolytic anemia?
With Mycoplasma infection, IgM is secreted and at lower temperatures, when mixed with RBC, cause RBC to stick together. Happens in 50% of cases of infection.