Hepatitis Viruses Flashcards Preview

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Flashcards in Hepatitis Viruses Deck (31)
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1

What are Hepatitis Viruses?

Viruses that specifically target the liver

2

Which Hepatitis Viruses are fecal-orally transmitted?

HAV, HEV

3

Which Hepatitis Viruses are primarilly sexually transmitted?

HBV, HCV, HDV

4

Which Hepatitis Viruses are common in the US?

Hepatitis A, B, and C

5

What virus is Hepatitis A similar to?

Poliovirus (Picornovirus)

6

What family does Hepatitis B virus belong to?

Hepadnaviridae

7

What type of genome does Hepatitis B have?

dsDNA

8

What type of virion does Hepatitis B have?

Enveloped

9

What virus has the smalled genome of the human viruses?

Hepatitis B

10

What is odd about the replication of Hepatitis B Virus?

Genome has an RNA intermediate after entering the nucleus.
It also produces many empty particles that do not contain genome.

11

What are the symptoms of Hepatitis B?

Genereal malaise, anorexia, comiting, fatigue, cough, serum-like sickness. Eventually Jaundice

12

Chronic Hepatitis B disease can lead to?

Cirrhosis of the liver which increases the risk of hepatocellular carcinoma

13

How is Hepatitis B prevented?

Recombinant vaccination is available (requires multiple innoculations - injection of synthesized viral particles)

14

How is chronic Hepatitis B treated?

Interferon-alpha therapy.

15

What is Hepatitis D Virus?

Subviral agent.
Requires active HBV infection

16

What family does Hepatitis C Virus belong to?

Flaviviridae

17

What type of genome does Hepatitis C have?

(+)ssRNA

18

What type of virion does Hepatitis C have?

Enveloped

19

How does translation occur in Hepatitis C virus?

Ribosomes recognise Internal Ribosome Entry Site (IRES)

20

How does Hepatitis C Virus differ from Hepatitis B Virus?

It is typically milder than HBV but chronic infections occur in approximately 80% of infections

21

How is Hepatitis A contracted?

Fecally contaminated food or water - absorbed through intestine and moves to liver via portal system

22

What are the symptoms of Hepatitis A virus?

Maliase, anorexia, vomiting, and jaundice

23

What other Hepatitis strain is Hepatitis E virus similar to? How do these two differ?

Hepatitis A - but it is life threatening to pregnant women.

24

What is the incubation time for HAV?

15-40 days

25

What is the incubation time for HBV?

60-180 days

26

What is the incubation time for HCV?

60-120 days

27

What is the incubation time for HDV?

60-180 days

28

What is the incubation time for HEV?

21-42 days

29

Which Hepatitis strains are capable of chronic infections?

HBV (5%) HCV (80%) and HDV

30

Which Hepatitis strains are enveloped? Non enveloped?

Enveloped - B/C/D
Non-Enveloped - A/E