Flashcards in Childhood Viruses Deck (36)
What type of genome does Measles Virus have?
What is the virion of the measles virus?
What is the replication process for measles?
After entry, (-)ssRNA must form mRNA which will be translated into proteins and eventually full genomes which travel to the cell surface and bud out.
How is Measles virus usually spread?
Inhalation of aerosolized droplets
How does measles virus interfere with the host immune system?
Interference with CD46 and signaling lymphocyte activation molecule (SLAM) receptors
What are the symptoms of measles virus?
2-3 days of fever + cough, coryza, and conjunctivitis. Rash.
What is the primary prevention method for measles virus?
Vaccination (live attenuated vaccine) provides life long immunity.
What type of genome does Respiratory Syncytial Virus have?
What type of virion does Respiratory Syncytial Virus have?
What is the target cell for Respiratory Syncytial Virus infection?
Ciliated cells in the respiratory tract epithelium
Is respiratory Syncytial Virus able to become a systemic infection?
RSV is limited to the respiratory tract
Does infection of Respiratory Syncytial Virus cause life long immunity?
No - Epitopes change often enough that your body will not recognize the next infection
How can you prevent Respiratory Syncitial Virus?
NO ANTIVIRALS; NO VACCINE...WASH HANDS
What Viral family does Measles Virus belong to?
What Viral family does Respiratory Syncitial Virus belong to?
What Viral family does Varicella Zoster Virus belong to?
What type of genome does Varicella Zoster Virus have?
What type of virion does Varicella Zoster Virus have?
What disease does Varicella Zoster Virus cause?
How does Varicella Zoster Virus replicate?
Must be in an active cell (can infect resting cell and cause latent infection).
What are the symptoms of Varicella Zoster Virus disease?
Fever, malaise, headache followed in 1-2 days by a rash.
What is the difference between smallpox and chickenpox?
Chickenpox is primarily on torso. Smallpox if face/arms/legs.
How is chickenpox prevented?
Antivirals - Acyclovir; Interferes with genome replication
What family of Virus does Poliovirus belong to?
What type of genome does Poliovirus have?
What type of virion does Poliovirus have?
How does Poliovirus (picornovirus) manipulate the cell for its own growth?
(+)ssRNA can be used as a template for translation when ribosomes attach to their IRES region. They also shut off host cell transcription of 5' caps so that the ribosomes do not bind to any host mRNA and they are forced to translate the viral (+)ssRNA
How is poliovirus spread?
Ingestion of contaminated material (fecal matter)
What prevention is available for poliovirus?
Two vaccines available - Salk (killed) and Sabin (live attenuated)