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Flashcards in Respiratory Viruses Deck (28)
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1

What type of genome does Influenze virus have?

SEgmented (-) ssRNA

2

What type of virion does Influenza virus have?

Enveloped

3

What type of genome does Adenovirus have?

dsDNA

4

What type of virion does Adenovirus have?

Non-enveloped

5

What type of genome does Rhinovirus have?

(+)ssRNA

6

What type of genome does Rhinovirus have?

Non-enveloped

7

What type of Influenza virus is most common and associated with greatest concern?

Influenza virus A

8

The Hemagglutinin (HA) protein in Influenza virus is associated with what?

Cell attachment

9

The Neuraminidase (NA) protein in Influenza virus is associated with what?

Viral budding and release

10

Which type of Influenze has animal reservoirs?

Type A

11

Where does transcription and replication of Influenza virus take place?

The nucleus

12

What are the symptoms of Influenza virus?

Fever, malaise, nonproductive cough, sore throat

13

What are complications of influenza virus?

Viral pneumonia, bacterial pneumonia, reye syndrome, otitis media

14

What strains of influenza do vaccines usually contain?

(Attenuated live vaccine) H3N2, H1N1, and Type B strain

15

What does Tamiflu do?

Blocks release of budding virions

16

How are adenovirus strains differentiated?

Serotype

17

What family of virus do adenovirus belong to?

Adenoviridae

18

How does Adenovirus enter the cell?

Via Coxsackie-adenovirus receptor (CAR) and then moves to the nucleus

19

What is unique about Adenovirus replication?

Occurs in three phases

20

What genes are made in the immediate-early phase of Adenovirus replication?

Transcriptional regulators (trying to take over the resources of the cell)

21

What genes are made in the early phase of Adenovirus replication

DNA replication and post transcriptional events

22

What genes are made in the late phase of Adenovirus replication?

Take over of cellular mRNA synthesis

23

Adenovirus needs the cell to be doing what in order to replicate?

The host cell must be replicating

24

How does Adenovirus promote a cell to be in a replication stage?

E1A inactivates pRb leading to S phase gene expression; E1B inactivates p53 leading to S phase and preventing apoptosis

25

What are symptoms of Adenovirus respiratory disease?

Common Cold - like nasal congestion, inflammation, cough (serotypes 1, 2, 5, 6); (Serotypes 4 and 7 can result in sever pneumonia in military recruits)

26

Rhinovirus causes what type of infections?

Mild upper respiratory infections

27

Why is it difficult to cure rhinovirus?

Over 100 serotypes makes vaccine development impractical

28

What are symptoms of Rhinovirus?

Common Cold - Red nose, nasal discharge