Respiratory Viruses

Question 1

What type of genome does Influenze virus have?

Answer 1

SEgmented (-) ssRNA

Question 2

What type of virion does Influenza virus have?

Answer 2

Enveloped

Question 3

What type of genome does Adenovirus have?

Answer 3

dsDNA

Question 4

What type of virion does Adenovirus have?

Answer 4

Non-enveloped

Question 5

What type of genome does Rhinovirus have?

Answer 5

(+)ssRNA

Question 6

What type of genome does Rhinovirus have?

Answer 6

Non-enveloped

Question 7

What type of Influenza virus is most common and associated with greatest concern?

Answer 7

Influenza virus A

Question 8

The Hemagglutinin (HA) protein in Influenza virus is associated with what?

Answer 8

Cell attachment

Question 9

The Neuraminidase (NA) protein in Influenza virus is associated with what?

Answer 9

Viral budding and release

Question 10

Which type of Influenze has animal reservoirs?

Answer 10

Type A

Question 11

Where does transcription and replication of Influenza virus take place?

Answer 11

The nucleus

Question 12

What are the symptoms of Influenza virus?

Answer 12

Fever, malaise, nonproductive cough, sore throat

Question 13

What are complications of influenza virus?

Answer 13

Viral pneumonia, bacterial pneumonia, reye syndrome, otitis media

Question 14

What strains of influenza do vaccines usually contain?

Answer 14

(Attenuated live vaccine) H3N2, H1N1, and Type B strain

Question 15

What does Tamiflu do?

Answer 15

Blocks release of budding virions

Question 16

How are adenovirus strains differentiated?

Answer 16

Serotype

Question 17

What family of virus do adenovirus belong to?

Answer 17

Adenoviridae

Question 18

How does Adenovirus enter the cell?

Answer 18

Via Coxsackie-adenovirus receptor (CAR) and then moves to the nucleus

Question 19

What is unique about Adenovirus replication?

Answer 19

Occurs in three phases

Question 20

What genes are made in the immediate-early phase of Adenovirus replication?

Answer 20

Transcriptional regulators (trying to take over the resources of the cell)

Question 21

What genes are made in the early phase of Adenovirus replication

Answer 21

DNA replication and post transcriptional events

Question 22

What genes are made in the late phase of Adenovirus replication?

Answer 22

Take over of cellular mRNA synthesis

Question 23

Adenovirus needs the cell to be doing what in order to replicate?

Answer 23

The host cell must be replicating

Question 24

How does Adenovirus promote a cell to be in a replication stage?

Answer 24

E1A inactivates pRb leading to S phase gene expression; E1B inactivates p53 leading to S phase and preventing apoptosis

Question 25

What are symptoms of Adenovirus respiratory disease?

Answer 25

Common Cold - like nasal congestion, inflammation, cough (serotypes 1, 2, 5, 6); (Serotypes 4 and 7 can result in sever pneumonia in military recruits)

Question 26

Rhinovirus causes what type of infections?

Answer 26

Mild upper respiratory infections

Question 27

Why is it difficult to cure rhinovirus?

Answer 27

Over 100 serotypes makes vaccine development impractical

Question 28

What are symptoms of Rhinovirus?

Answer 28

Common Cold - Red nose, nasal discharge