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Flashcards in Neurological Viruses Deck (25)
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1

What vectors are involved in arthropod transmission?

Mosquitoes/Ticks

2

What reservoirs are involved in arthropod transmission?

Birds/Small Mammals

3

What family of Virus do Eastern Equine Encephalitis Virus and Venezuelan Equine Encephalitis Virus belong to?

Togaviridae

4

What type of genomes do EEE and VEE have?

(+)ssRNA

5

What type of virion do EE and VEE have?

Enveloped

6

Where do surface proteins of EEE and VEE go before going to cell surface and meeting capsid proteins?

ER/Golgi

7

When EEE and VEE Viruses replicate, what is unique?

They have an early and a late stage of replication. (Replication complex made in early stage)(Minue strand translated to form capsid proteins)

8

What are EEE and VEE's mechanism of infection?

Through bite of infected arthropod - Carried by Langerhans cells to LN - Replication and release into blood stream. Could potentially pass blood/brain barrier and enter CNS

9

What are the symptoms of EEE & VEE?

Systemic disease - Chills, fever, malaise, arthralgia, myalgia

10

What prevention measures are available for EEE and VEE?

No vaccine for humans
Veterinary vaccine for animals
Mosquito control/repellant

11

What treatment is available for EEE and VEE?

No treatment - supportive care

12

What percentage of West Nile Virus infections are asymptomatic?

80%

13

What type of viral family does West Nile Virus belong to?

Flavaviridae

14

When West Nile Virus is neruoinvasive, what happens?

Aseptic meningitis, encephalitic, flaccid paralysis, altered mental state, tremors.
50% of survivors have sequelase 12 months later

15

How is west Nile Virus prevented?

No vaccine/treatment
Mosquito control/repellant

16

What family does Rabies Virus belong to?

Rhadoviridae

17

What type of genome do rabies viruses have?

(-)ssRNA

18

What type of virion do Rabies viruses have?

Enveloped

19

What shape does the rabies virus have?

Bullet-shaped

20

What is unique about rabies virus replication?

Made in sequence - early genes are made in greater quantities.

21

What type of tropism does rabies virus have?

Broad tropism (can infect a broad array of animals/humans)

22

How does rabies virus spread once ingested?

Gradually moves from bite site to CNS. Moves passively through nervous system. Also spread back to salivary glands.

23

What are some symptoms of Rabies virus?

Prickling or itching where bitten, fever, headache, hydrophobia, cerebral dysfunction, anxiety, confusion, delirium, hallucinations, and insomnia

24

What is the mortality rate of Rabies infections?

Once symptoms appear, it is almost always fatal.

25

How are Rabies Viruses treated?

Vaccine can be administered immediately after bites
Animals should also be vaccinated preemptively.