Flashcards in Cholinergic/Adrenergic Drugs Deck (26):
What kind of drug is Atropine? Used for?
Reversible, non-selective mAChR antagonist
Used to tx organophosphate poisoning, symptomatic bradycardia, to block vagal reflex in surgery. Contraindicated in glaucoma patients.
What kind of drug is Pralidoxime? Used for?
Cholinesterase regenerator (so helps degrade Ach in NMJ)
Used to tx organophosphate poisoning
What kind of drug is Bethanechol? Used for?
Selective charged mAChR agonist, used to tx urinary retention (M3)
What kind of drug is Carbachol? Used for?
Nonspecific cholinergic agonist.
Used to tx glaucoma/produce miosis during surgery/exams
What kind of drug is Cevimeline? Use?
Direct-acting cholinergic agonist. Used to treat dry mouth (xerostomia) in patients with Sjogrens. Contraindicated in asthma patients.
What kind of drug is Pilocarpine? Use?
Direct mAChR agonist. Used to treat xerostomia, for miosis and glaucoma.
What kind of drug is Acetylcholine? What is its approved use?
Cholinergic agonist. Used intraocularly for miosis during eye surgery.
What kind of drug is Varenicline (Chantix)?
Partial agonist that binds with high affinity to a4b2 nAChRs. Used for smoking cessation
What kind of drugs are Ipratropium and tiotropium? Use?
Inhalation mAChR antagonists. Used for asthma, COPD
What kind of drug is Oxybutynin? Use?
Selective M3 antagonist. Can be used for GU disorders (incontinence and diarrhea) But has side effects of dry mouth/eyes
What kind of drug is Phenylephrine? Use?
Selective alpha1 agonist. Used for hypotensive emergencies, priapism, mydriasis, decongestant
What kind of drug is Clonadine? Use?
Selective alpha2 agonist. Causes bradycardia d/t decreased NE release. Used for chronic HTN.
What kind of drug is Isoproterenol? Effect?
Non-selective beta agonist. Causes potent inotropic/chronotripic action, vasodilation, bronchodilation
What kind of drug is Dobutamine? Use?
Selective b1 agonist, used for heart failure, cariogenic shock.
What kind of drugs are Tertbutaline and Albuterol? Use?
Selective beta2 agonists. Used for asthma.
What drug class are Amphetamine, methamphetamine, and methylphenidate in and what do they do?
Indirect adrenergic agonists, act as VMAT substrates, increase NE. For ADHD, obesity, narcolepsy
What drug class is Epinephrine in? Used for?
Nonselective adrenergic agonist a1=a2, b1=b2. Tx of anaphylaxis.
What drug class is Phentolamine in? Used for?
Competitive alpha (a1=a2) antagonist. Used to tx pheochromocytoma.
What drug class is Prazosin in? Used for?
Irreversible a1 antagonist. Used to tx pheochromocytoma.
What drug class is Physostigmine? Used for?
uncharged AChE inhibitor, increases ACh levels
What drug class is Propranolol? Use?
b1=b2 antagonist. Used for HTN, MI.
What is the suffix of a1 selective antagonists?
-osin (i.e. prazosin, terazosin)
What drug class is Ephedrine in? Use?
Indirect adrenergic agonist (releases stored catecholamines). Mild stimulant, used for hypotension, decongestion, anaphylaxis.
What kind of drug is Cocaine? Effects?
Indirect adrenergic agonist, inhibits NE/dopamine reuptak (via blocking MOT). Causes adrenomimetic action.
What drug class are the amphetamines? Use?
Indirect adrenergic agonists, reverse DA/NE re-uptake and increse release. Used for ADHD, obesity.