Flashcards in Neuropathology 1 Deck (16):
CSF findings in bacterial meningitis?
Purulent/cloudy CSF, increased pressure, increased protein count, reduced glucose count, high neutrophils
CSF findings in aseptic (viral) meningitis?
Lymphocytic pleocytosis, moderate protein elevation, normal glucose content
CSF findings in brain abscess?
High white cell count, increased protein concentration, normal glucose content
What are sx/CSF findings in a subdural empyema?
CSF-High white cell count, increased protein concentration, normal glucose content. Subdural empyema will be febrile, with HA and stiff neck.
What is nearoborreliosis?
Lyme disease manifestation wi/highly variable symptoms including aseptic meningitis, facial nerve palsy, encephalopathy
What manifestations does CMV have in utero?
In utero-> periventricular necrosis-> brain destruction, microcephaly, periventricular calcifications
How does acute hypertensive encephalopathy present?
malignant HTN-> increased intracrainial pressure with HA, vomiting, convulsions, cerebral dysfunction
What are the sx and epidemiology of HSV-1?
Most common in children and young adults
Presenting sx-> changes in mood, memory, behavior and oral lesions
What is the morphology of CMV in the brain?
Localizes in periventricular subepyndymal area of brain-> severe, hemorrhagic necrotizing ventriculoencephalitis, choroid plexitis
Most common organisms that cause meningitis in neonates?
Group B strep, Listeria, and E. Coli
Teen/Young adult that presents with meningitis sx and petechiae.... first thought should be?
Uncal herniations often compress what structures?
CN3, PCA compressions
What is an Arnold Chiari malformation?
Small posterior fossa, displacement of vermis through foramen magnum
What is a Dandy-Walker malformation?
Enlarged posterior fossa, absent cerebellar vermis, often dilated 4th ventricle. Will have slow motor development, unsteadiness, trouble with voluntary motion.
How would multi cystic encephalopathy present?
In a neonate after prolonged ischemia-> cystic lesions throughout both hemispheres