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Flashcards in Neuropathology 1 Deck (16):
1

CSF findings in bacterial meningitis?

Purulent/cloudy CSF, increased pressure, increased protein count, reduced glucose count, high neutrophils

2

CSF findings in aseptic (viral) meningitis?

Lymphocytic pleocytosis, moderate protein elevation, normal glucose content

3

CSF findings in brain abscess?

High white cell count, increased protein concentration, normal glucose content

4

What are sx/CSF findings in a subdural empyema?

CSF-High white cell count, increased protein concentration, normal glucose content. Subdural empyema will be febrile, with HA and stiff neck.

5

What is nearoborreliosis?

Lyme disease manifestation wi/highly variable symptoms including aseptic meningitis, facial nerve palsy, encephalopathy

6

What manifestations does CMV have in utero?

In utero-> periventricular necrosis-> brain destruction, microcephaly, periventricular calcifications

7

How does acute hypertensive encephalopathy present?

malignant HTN-> increased intracrainial pressure with HA, vomiting, convulsions, cerebral dysfunction

8

What are the sx and epidemiology of HSV-1?

Most common in children and young adults
Presenting sx-> changes in mood, memory, behavior and oral lesions

9

What is the morphology of CMV in the brain?

Localizes in periventricular subepyndymal area of brain-> severe, hemorrhagic necrotizing ventriculoencephalitis, choroid plexitis

10

Most common organisms that cause meningitis in neonates?

Group B strep, Listeria, and E. Coli

11

Teen/Young adult that presents with meningitis sx and petechiae.... first thought should be?

Nesseria meningiditis

12

Uncal herniations often compress what structures?

CN3, PCA compressions

13

What is an Arnold Chiari malformation?

Small posterior fossa, displacement of vermis through foramen magnum

14

What is a Dandy-Walker malformation?

Enlarged posterior fossa, absent cerebellar vermis, often dilated 4th ventricle. Will have slow motor development, unsteadiness, trouble with voluntary motion.

15

How would multi cystic encephalopathy present?

In a neonate after prolonged ischemia-> cystic lesions throughout both hemispheres

16

What is Guillan-Barre?

Autoimmune disease that affects Schwann cells-> results in ascending paralysis (often after CMV or C. jejuni infection)