Local Anesthetics Flashcards Preview

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Flashcards in Local Anesthetics Deck (14):
1

What is the MOA of local anesthetics?

Bind to and block VG Na+ channels-> block action potential

2

What is the rule of "I's" for amides/esthers?

Esters have one "I"
Amides have two "I's"

3

What anesthetic is only used topically?

Benzocaine

4

What is the only use of Procaine?

aka Novocain-> used for infiltration anesthesia (i.e. for dental work)

5

In addition to local anesthesia, what other use does Lidocaine have?

Used as an anti-arrhythmic agent

6

What side effects do low concentrations of local anesthetics have on the CNS?

Sleepiness, restlessness, light-headedness

7

What CNS effects can high concentrations of local anesthetics have?

Nystagmus, muscular twitching, convulsions

8

If a patient is allergic to Procaine, what else will they likely be allergic to?

Other ester drugs-> tetracaine, benzocaine, etc.
Use an amide drug instead

9

How is cocaine a unique anesthetic?

Has intrinsic vasoconstrictive properties, causes euphoria

10

What amide anesthetic has a long DOA and can produce prolonged anesthesia?

Bupivicaine

11

What commonly-used local anesthetic has a medium DOA and is a good choice for people sensitive to esther-type anesthetics?

Lidocaine

12

What is the primary medical use of cocaine?

As a topical anesthetic of upper respiratory tract

13

What size nerve does local anesthesia block first?

Small fibers (like type B and C)

14

If two nerves are the same size, which one will be blocked first by local anesthesia?

The one that is more myelinated (i.e. B fibers are blocked before unmyelinated C fibers)