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Pharm I > Cholinergic Drugs > Flashcards

Cholinergic Drugs Flashcards

(49 cards)

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1
Q

Carbachol MOA

A

nicotinic and muscarinic agonist
stimulates autonomic ganglia - ACh release

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2
Q

Carbachol Therapeutic Uses

A

rumen atony and impaction in cattle
impaction colic in horses
glaucoma in dogs

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3
Q

Bethanechol MOA

A

muscarinic agonist

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4
Q

Bathanechol Therapeutic Use

A

uriniary retention

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5
Q

Pilocarpine MOA

A

M3 agonist - constraction of sphincter of iris and ciliary muscle of lens

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6
Q

Pilocarpine Therapeutic Use

A

glaucoma in dogs

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7
Q

Physostigmine MOA

A

reversible AChE inhibitor
indirect acting cholinergic agonist

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8
Q

Physostigmine Therapeutic Uses

A

glaucoma
antidote for atropine toxicity

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9
Q

Physostigmine Adverse Effects

A

large doses = convulsions

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10
Q

Neostigmine MOA

A

reversible AChE inhibitor
indirect acting cholinergic agonist

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11
Q

Neostigmine Therapeutic Use

A

myasthenia gravis
anti-curare

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12
Q

Neostagmine Adverse Effects

A

toxicity = skelteal muscle weakness

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13
Q

Edrophonium MOA

A

reversible AChE inhibitor
indirect cholinergic agonist

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14
Q

Edrophonium Therapeutic Use

A

diagnosis of myasthenia gravis

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15
Q

Edrophonium Adverse Effects

A

bradycardia

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16
Q

Pyridostigmine MOA

A

reversible AChE inhibitor
indirect cholinergic agonist
longer acting

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17
Q

Organophosphorus Compounds MOA

A

irreversible AChE inhibitor

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17
Q

Pyridostigmine Therapeutic Use

A

managment of myasthenia gravis

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17
Q

Pralidoxime MOA

A

acts on phosphorylated esteratic site of AChE - reactives AChE

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18
Q

Pralidoxime Therapeutic Use

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A

organophosphate poisoning

19
Q

Atropine MOA

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A

competitive cholinergic antagonist
inhibits muscarinic actions of ACh

20
Q

Atropine Therapeutic Effects

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A

antidote for cholinergic agonists

21
Q

Atropine Adverse Effects

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A

atropine poisoning

22
Q

Treatment for Atropine Poisoning

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A

neostigmine
physostigmine

23
Scopolamine MOA
cholinergic antagonist
24
Scopolamine Therapeutic Uses
prevention of motion sickness
25
Pirenzepine MOA
M1 chonlinergic antagonist
26
Pirenzepine Therapeutic Effects
reduces gastric acid secretion
27
Tropicamide MOA
cholinergic antagonist
28
Tropicamide Therapeutic Uses
mydriatic and cyclopegic treat adhesion between iris and lens
29
Glycopyrrolate MOA
synthetic antimuscarinic cholinergic antagonist
30
Glyopyrrolate Therapeutic Uses
preanesthetic
31
Homatropine MOA
synthetic antimuscarinic
32
Homatropine Therapeutic Uses
mydriasis cycloplegia
33
Ipratropium MOA
synthetic antimuscarinic
34
Ipratropium Therapeutic Uses
relief if bronchodilation
35
Methantheline MOA
synthetic antimuscarinic
36
Propantheline MOA
synthetic antimuscarinic
37
Propantheline Therapeutic Uses
smooth muscle relaxant
38
Methylatropine MOA
synthetic antimuscarnic
39
Methylatropine Therapeutic Uses
smooth muscle relaxant
40
Dicyclomine MOA
synthetic muscarinic
41
Dicyclomine Therapeutic Uses
smooth muscle relaxant
42
Hexamethonium MOA
antogonizes nicotinic effect of ACh on autonomic ganglia
43
Trimetaphan MOA
competitive nicotinic ganglionic blocker
44
Trimetaphan Therapeutic Uses
emergency lowering of BP
45
Nicotine MOA
autonomic ganglionic blocker
46
Non-Depolarizing Neuromuscular Blocker MOA
competitive inhibition of nicotinic receptors
47
Depolarizing Neuromuscular Blocker MOA
acts like ACh - depolarizes the NM junction, peristent depolarization = NM blockade

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