NSAIDs

Question 1

Asprin aka

Answer 1

acetylsalicylic acid

Question 1

Acetylsalicylic acid adverse effects

Answer 1

prolonged bleeding time
GI irritant - not to be used in gastric ulcerative conditions

Question 2

Acetylsalicylic acid metabolism

Answer 2

metabolized to salicylic acid in the liver

Question 3

Consideration when administering acetylsalicylic acid

Answer 3

consider when last dose was before performing surgery
do not use in patients with possible spinal cord trauma

Question 4

Phenylbutazone MOA

Answer 4

non-selective COX inhibitor

Question 5

Phenylbutazone therapeutic uses

Answer 5

anti-inflammatory in horses and dogs
osteoarthritis
laminitis
colic

Question 6

Phenylbutazone adverse effects

Answer 6

hepatic toxicity
GI ulceration
bone marrow hypoplasia
renal papillary necrosis
more toxic to foals
promotes Na+ and water retention - caution in cardiovascular patients
depression in dogs

Question 7

Phenylbutazone metabolism

Answer 7

metabolized in liver to oxyfenbutazone

Question 8

Is phenylbutazone okay to use in dairy cattle?

Answer 8

no - prohibited in dairy cows older than 20 months
which can cross the placenta and be detected in milk

Question 9

Flunixin megluamine MOA

Answer 9

non-selective COX inhibitor
blocks prostanoid synthesis related to endotoxemia

Question 10

Flunixin megluamine therapeutic use

Answer 10

horses: musculoskeletal anti-inflammatory, colic, endotoxic shock
cattle: acute mastitis, acute pulmonary emphysemia, endotoxemia
dogs: septic shock
swine: control pyrexia associated with respiratory disease

Question 11

Flunixin megluamine withdrawal period in cattle and swine

Answer 11

4 days in cattle
12 days in swine

Question 12

Can flunixin megluamine be used in dairy cows and veal calves?

Answer 12

NOOOO

Question 13

Naproxen MOA

Answer 13

non-selective COX inhibitor

Question 14

Naproxen therapeutic use

Answer 14

myositis
soft-tissue inflammation
good for horses

Question 15

Naproxen metabolism

Answer 15

enterohepatic circulation - prolonged elimination half-life

Question 16

Ibuprofen MOA

Answer 16

non-selective COX inhibitor

Question 17

Ibuprofen adverse effects

Answer 17

NOT recommended for dogs
GI disturbances
vomiting

Question 18

Meclofenamic acid MOA

Answer 18

NSAID
slow onset

Question 19

Meclofenamic acid therapeutic uses

Answer 19

preferred for horses

Question 20

Ketoprofen adverse effects

Answer 20

GI upset
nephritis

Question 21

Ketoprofen therapeutic uses

Answer 21

used in horses, cattle, swine, dogs, cats
anti-inflammatory
analgesic
anti-pyretic
horses: musculoskeletal disorders

Question 22

Ketoprofen MOA

Answer 22

inhibits COX and LOX
inhibits bradykinin

Question 23

Diclofenac therapeutic use

Answer 23

horses: osetoarthritis in limbs
topical cream

Question 24

Carprofen MOA

Answer 24

COX-2 inhibitor inhibits phospholipase - blocks release of arachidonic acid

Question 25

Carprofen therapeutic use

Answer 25

for dogs, cats, horses, cattle osteoarthritis post-op pain

Question 26

Carprofen adeverse effects

Answer 26

hepatoxic

Question 27

Carprofen metabolism

Answer 27

metabolized in the liver excreted in the feces enterohepatic recycling

Question 28

Meloxicam MOA

Answer 28

COX-2 inhibitor

Question 29

Meloxicam therapeutic use

Answer 29

Dogs: osteoarthritis Cats: post-op pain and inflammation associated with orthopedic surgery, ovariohysterectomy, castration (pain for surgeries)

Question 30

Piroxicam MOA

Answer 30

inhibits new blood vessel formation

Question 31

Piroxicam therapeutic use

Answer 31

osteoarthtitis in dogs transitional cell tumors musculoskeletal inflammatory conditions

Question 32

Deracoxib MOA

Answer 32

COX-2 inhibitor

Question 33

Dercoxib therapeutic use

Answer 33

osteoarthitis post-op orthopedic and dental pain mostly used in dogs

Question 34

Dercoxib bioavailability

Answer 34

imoroved when administered with food

Question 35

Firocoxib MOA

Answer 35

COX-2 inhibitor

Question 36

Firocoxib therapeutic use

Answer 36

Dog: inflammation associated w/ osteoarthritis, and soft-tissue surgery Horses: control pain and inflammation with osteoarthritis —use recommended for 14 days

Question 37

How old must a dog be in order to be prescribed firocoxib?

Answer 37

for use in dogs weighing more than 12.5lbs and 7months of age or older

Question 38

Robenacoxib aka

Answer 38

ONSIOR

Question 39

Robenacoxib MOA

Answer 39

COX-2 inhibitor

Question 40

Robenacoxib therapeutic use

Answer 40

post-op pain and inflammation

Question 41

What animals is Robenacoxib approved for use in?

Answer 41

dogs and cats

Question 42

How old must a cat be in order to be prescribed robenacoxib?

Answer 42

for use in cats weighing more than 5.5lbs and are 4 months of age or older

Question 43

How long can cats be on robenacoxib?

Answer 43

no longer than 3 days

Question 44

Mavacoxib MOA

Answer 44

COX-2 inhibitor

Question 45

Mavacoxib therapeutic use

Answer 45

degenerative joint disease

Question 46

Half-life and dosing of mavacoxib

Answer 46

half-life of 17 days do not exceed 7 doses

Question 47

Metabolism of mavacoxib

Answer 47

biliary excretion

Question 48

Tepoxalin MOA

Answer 48

COX and LOX inhibitor

Question 49

Tepoxalin therapeutic use

Answer 49

dogs: osteoarthitis

Question 50

Tepoxalin metabolism

Answer 50

metabolite = tepoxalin pyrazol acid half-life 12-14 hours

Question 51

Etodolac MOA

Answer 51

COX-2 inhibitor inhibit macrophage chemotaxis

Question 52

Etodolac therapeutic use

Answer 52

dogs: osteoarthitis

Question 53

Acetaminophen therapeutic use

Answer 53

analgesic antupyretic

Question 54

Acetaminophen adverse effects

Answer 54

toxicity - emergency condition cats: heptatoxic, methemoglobinemia

Question 55

Acetaminophen metabolism

Answer 55

toxic metabolite = NAPQI - CYP420 enzyme causing Heinz bodies = hepatotoxic

Question 56

Cimetidine MOA

Answer 56

inhibut metabolism of acetaminophen H2 blocker

Question 57

Cimetidine therapeutic use

Answer 57

emergency treatment of acetaminophen toxicity

Question 58

N-acetly-cysteine MOA

Answer 58

precursor of glutathione conjugates NAPQI - facilitates elimination

Question 59

N-acetly-cysteine therapeutic use

Answer 59

emergency treatment of acetaminophen toxicity

Question 60

When should N-acetly-cysteine be administered?

Answer 60

must be given before liver damage occurs