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Pharm I > Local Anesthetics > Flashcards

Local Anesthetics Flashcards

(40 cards)

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1
Q

Procaine onset of action

A

slow

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2
Q

Procaine duration of action

A

45-60 min

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3
Q

Procaine therapeutic use

A

used in conjunction with penicillin G to slow it’s release into systemic circulation

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4
Q

Procaine adverse effects

A

PABA - allergic reaction

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5
Q

Procaine lipid solubility

A

lowe

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6
Q

Procaine metabolite

A

PABA

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7
Q

Procaine linkage type

A

amino-ester linkage

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8
Q

Benzocaine linkage type

A

amino-ester linkage

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9
Q

Benzocaine solubility

A

very low solubility

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10
Q

Benzocaine therapeutic use

A

fish anesthesia
throat pain

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11
Q

Lidocaine linkage type

A

amide-linkage

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12
Q

Lidocaine onset of action

A

2-5 min
fast

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13
Q

Lidocaine duration of action

A

60-120 min

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14
Q

Lidocaine Therapeutic Use

A

local anesthetic
nerve block
IVRA
spinal anesthesia
endotracheal intubation
emergency anti-arrhythmic drug in dogs

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15
Q

Lidocaine adverse effects

A

high concentrations = CNS toxicity

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16
Q

Mepivacaine onset of action

A

rapid

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17
Q

Mepivacaine duration of action

18
Q

Mepivacaine therapeutic use

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A

equine limb blocks

19
Q

Mepivacaine benefits

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A

less post injection edema

20
Q

Mepivacaine linkage type

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A

amide-linkage

21
Q

Bupivacaine onset of action

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A

20-30 min
slow

22
Q

Bupivacaine linkage type

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A

amide-linkage

23
Q

Bupivacaine duration of action

24
Q

Bupivacaine therapeutic use

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A

infiltration
nerve blocl
intra-pleural anesthesia
spinal anesthesia
dental blocks

25
Dental Block drug combination
lidocaine + bupivacaine 1:4 ratio
26
Bupivacaine Adverse Effects
CVS toxicity dysrhythmia
27
Intralipid therapeutic use
treat CVS toxicity caused by bupivacaine
28
Ropivacaine linkage type
amide-linkage
29
Ropivacaine onset of action
slow
30
Ropivacaine duration of action
360 min
31
Ropivacaine therapeutic use
Spinal anesthesia - diaphasic effect
32
EMLA therapeutic use
human use - derm, analgesia
33
EMLA components
mizture of lidocaine and prilocaine
34
What type of linkages do ophthalmic local anesthetics have?
amino-ester linkages
35
Proparacaine onset of action
fast
36
Proparacaine duration of action
45 min dogs 15 min cats
37
Tetracaine potency
more potent than proparacaine - lower dose, longer duration of action
38
Ophthalmic Local Anesthetics Therapeutic Uses
tonometry conreal exam biopsy foreign body removal and suturing
39
Additional use of Tetracaine
used at lower doses for spinal anesthesia
40
MOA for all local anesthetics
block the propagation of AP by inhibiting the influx of Na+ through Navs

Pharm I (15 decks)

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