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Drugs 183 > Class#3 - Toxicology > Flashcards

Class#3 - Toxicology Flashcards

1
Q

Junk food contains

A

Dioxins

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2
Q

Bread

A

Acrylamide

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3
Q

Chlorinated water

A

trihalomethane

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4
Q

Polyester bottled water

A

Antimony

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5
Q

Nail polish

A

Dibutyl Phtalate

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6
Q

POlyeruthane pillows

A

Isocyanates

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7
Q

Rubber

A

Nitrosamines

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8
Q

ADL determined by

A

1/100th of NOAEL

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9
Q

Discovered curare caused musc. relaxation

A

Sir Charles Waterton

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10
Q

Discovered curare blocks nerve impulse from CNS

A

Claude Bernard

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11
Q

1st to use curare in surgery

A

Dr. Harold Griffith in 1942 in Mtl

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12
Q

Sulfanilamide use and problem, b/c of who? Led to?

A

ATB for gonorrhea/strep troat, disolved in diethyl Glycol by Watkins. 1938 Food and Cosmetic Act

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13
Q

Sulfanilamide mixture killed?

A

107, mostly childs and 206 desabilities

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14
Q

Who connected death to diethyl glycol?

A

Frances Kelsey (McGill)

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15
Q

Hormesis?

A

Study Rx at very low doses

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16
Q

Super smal dose toxic eg?

A

Vit. A also BPA

17
Q

Risk=

A

Exposure * Toxicity

18
Q

Lima beans contains?

19
Q

Cassava fruits contains?

A

Toxic dose of cyanide, lethal 10 000mcg

20
Q

Puffer fish

A

Tetrodotoxins lethal 10mcg

21
Q

Clostridium Botulism lethal dose

22
Q

Chocolote toxic to animals b/c

A

Cannot metabolize theobromine

23
Q

Difficulties in toxicology?

A

Type of exposure, biochemical individualtity, Acute vs Chronic, Teratogenic effects, Toxins recognition, animal models

24
Q

BBQ meat froms

A

Benzopyrenes

25
Inducing detox
Catechins in green tea, Glutathione-s-transferase in garlic, JOhn's Wort stimulate P450
26
Cyclosporine problem with?
jonhns wort
27
Normal acéta metabolism?
Glucoronyl transferase
28
When too much acéta?
p450 makes acéta into molecule that causes liver damage. N-Acétylcystéine ->Gluthathione-s-transferase detox.
29
Enz. making bilirubin detox
Glucoronyl Transferase
30
1st non-sedating antihistamine, however with... accumulates.
Seldane, Ketoconazole
31
Allegra is?
Metabolic active form of seldane
32
What in grapefruit inhibits p450?
Furanocoumarins
33
Age cheese contains? bad with MAOI b/c?
Tyramine, increase BP if not broken down by MAO
34
Dioxins all contains?
Central oxygen with 4 cl
35
Toxic dioxin?
TCDD
36
dioxins come from?
Auxins, are plant growth hormone
37
TCDD byproduct of?
2,4,5 - T

Drugs 183 (13 decks)

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